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[1]齊新宇,熊輝,周彪,等.蠲痹歷節(jié)清方干預(yù)雞急性痛風(fēng)性關(guān)節(jié)炎模型的 實(shí)驗(yàn)研究[J].中醫(yī)正骨,2015,27(03):5-11.
　QI Xinyu,XIONG Hui,ZHOU Biao,et al.Juanbilijieqing Fang(蠲痹歷節(jié)清方)interfere with acute gouty arthritis chiken model[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(03):5-11.
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蠲痹歷節(jié)清方干預(yù)雞急性痛風(fēng)性關(guān)節(jié)炎模型的 實(shí)驗(yàn)研究()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第27卷
期數(shù):
2015年03期
頁碼:
5-11
欄目:
基礎(chǔ)研究
出版日期:
2015-03-30

文章信息/Info

Title:
Juanbilijieqing Fang(蠲痹歷節(jié)清方)interfere with acute gouty arthritis chiken model
作者:
齊新宇1; 熊輝2; 周彪1; 向黎黎1; 李騰龍1; 郭玉星1; 陸小龍2
1.湖南中醫(yī)藥大學(xué),湖南 長沙 410208;
2.湖南中醫(yī)藥大學(xué)第二附屬醫(yī)院,湖南 長沙 410005
Author(s):
QI Xinyu1; XIONG Hui2; ZHOU Biao1; XIANG Lili1; LI Tenglong1; GUO Yuxing1; LU Xiaolong2
1.Hunan University of Traditional Chinese Medicine,Changsha 410208,Hunan,China
2.The Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha 410005,Hunan,China
關(guān)鍵詞:
關(guān)節(jié)炎; 痛風(fēng)性;  蠲痹歷節(jié)清方;  疾病模型; 動(dòng)物;  尿酸;  黃嘌呤氧化酶;  動(dòng)物實(shí)驗(yàn)
Keywords:
arthritis; gouty;  Juanbilijieqing Fang;  disease models; animal;  uric acid;  xanthine oxidase;  animal experimentation
摘要:
目的:觀察蠲痹歷節(jié)清方干預(yù)雞急性痛風(fēng)性關(guān)節(jié)炎模型的療效,并探討其可能的作用機(jī)制。方法:將160只30日齡雄性湘黃雞隨機(jī)分為對(duì)照組、模型組、蠲痹歷節(jié)清方組及別嘌醇組,每組40只。對(duì)照組以正常飼料喂養(yǎng); 其余3組以蛋白含量為50%的飼料喂養(yǎng),連續(xù)喂養(yǎng)21 d制成急性痛風(fēng)性關(guān)節(jié)炎模型。自造模結(jié)束后第1天開始,蠲痹歷節(jié)清方組及別嘌醇組分別以蠲痹歷節(jié)清方湯劑和別嘌醇溶液灌胃,其余2組均以生理鹽水灌胃,每日2次,共21 d。分別于藥物干預(yù)開始后1、7、14、21 d在每組隨機(jī)選出10只雞,分別觀察其一般狀態(tài)、踝關(guān)節(jié)周徑、血尿酸含量和血清黃嘌呤氧化酶(xanthine oxidase,XOD)活性,隨后處死動(dòng)物,分離出左側(cè)踝關(guān)節(jié)滑膜組織,光鏡下觀察其滑膜組織形態(tài)。結(jié)果:①一般狀態(tài)。除對(duì)照組外,其余3組動(dòng)物藥物干預(yù)開始時(shí)精神萎頓,羽毛松亂、灰暗無光澤,飲食減退,雙膝與雙踝關(guān)節(jié)腫大,跛行,站立不穩(wěn),糞便中白色物質(zhì)增多。至藥物干預(yù)后21 d時(shí),蠲痹歷節(jié)清方組和別嘌醇組動(dòng)物一般狀態(tài)基本恢復(fù)正常; 模型組動(dòng)物一般狀態(tài)較開始時(shí)好轉(zhuǎn),但表現(xiàn)較蠲痹歷節(jié)清方組和別嘌醇組差; 對(duì)照組動(dòng)物除體質(zhì)量增加外,其余表現(xiàn)與造模前一致。造模及實(shí)驗(yàn)過程中各組均無動(dòng)物死亡。②踝關(guān)節(jié)周徑。藥物干預(yù)開始后各時(shí)點(diǎn),4組動(dòng)物踝關(guān)節(jié)周徑比較,組間差異均有統(tǒng)計(jì)學(xué)意義(F=25.172,P=0.000; F=24.445,P=0.000; F=21.237,P=0.014; F=29.881,P=0.041)。藥物干預(yù)開始后1、7、14 d時(shí),模型組、蠲痹歷節(jié)清方組及別嘌醇組踝關(guān)節(jié)周徑均大于對(duì)照組(P=0.001,P=0.001,P=0.001; P=0.002,P=0.002,P=0.001; P=0.001,P=0.002,P=0.001); 藥物干預(yù)開始后7、14 d時(shí),蠲痹歷節(jié)清方組和別嘌醇組踝關(guān)節(jié)周徑均小于模型組(P=0.025,P=0.014; P=0.012,P=0.011); 藥物干預(yù)開始后21 d時(shí),對(duì)照組、蠲痹歷節(jié)清方組及別嘌醇組踝關(guān)節(jié)周徑均小于模型組(P=0.001,P=0.015,P=0.013); 其余各時(shí)點(diǎn)各組間兩兩比較,組間差異均無統(tǒng)計(jì)學(xué)意義。③血尿酸含量。藥物干預(yù)開始后各時(shí)點(diǎn),4組動(dòng)物血尿酸含量比較,組間差異均有統(tǒng)計(jì)學(xué)意義(F=25.361,P=0.003; F=32.371,P=0.005; F=36.734,P=0.021; F=48.336,P=0.023)。藥物干預(yù)開始后1、7、14 d時(shí),模型組、蠲痹歷節(jié)清方組及別嘌醇組血尿酸含量均大于對(duì)照組(P=0.000,P=0.001,P=0.001; P=0.001,P=0.001,P=0.002; P=0.001,P=0.000,P=0.001); 藥物干預(yù)開始后7、14 d時(shí),蠲痹歷節(jié)清方組和別嘌醇組血尿酸含量均小于模型組(P=0.011,P=0.010; P=0.014,P=0.002); 藥物干預(yù)開始后21 d時(shí),對(duì)照組、蠲痹歷節(jié)清方組及別嘌醇組血尿酸含量均小于模型組(P=0.001,P=0.012,P=0.011); 其余各時(shí)點(diǎn)各組間兩兩比較,組間差異均無統(tǒng)計(jì)學(xué)意義。④血清XOD活性。藥物干預(yù)開始后各時(shí)點(diǎn),4組動(dòng)物血清XOD活性比較,組間差異均有統(tǒng)計(jì)學(xué)意義(F=45.721,P=0.001; F=50.634,P=0.002; F=49.448,P=0.013; F=63.124,P=0.027)。藥物干預(yù)開始后1、7、14 d時(shí),模型組、蠲痹歷節(jié)清方組及別嘌醇組血清XOD活性均高于對(duì)照組(P=0.002,P=0.001,P=0.001; P=0.001,P=0.000,P=0.001; P=0.001,P=0.001,P=0.000); 藥物干預(yù)開始后7、14 d時(shí),蠲痹歷節(jié)清方組和別嘌醇組血清XOD活性均低于模型組(P=0.001,P=0.013; P=0.002,P=0.015); 藥物干預(yù)開始后21 d時(shí),對(duì)照組、蠲痹歷節(jié)清方組及別嘌醇組血清XOD活性均低于模型組(P=0.001,P=0.013,P=0.017); 其余各時(shí)點(diǎn)各組間兩兩比較,組間差異均無統(tǒng)計(jì)學(xué)意義。⑤滑膜組織形態(tài)。藥物干預(yù)開始后各時(shí)點(diǎn),4組動(dòng)物滑膜中血管數(shù)量比較,組間差異均有統(tǒng)計(jì)學(xué)意義(F=24.772,P=0.032; F=33.176,P=0.021; F=32.672,P=0.003; F=44.351,P=0.000)。藥物干預(yù)開始后1、7、14 、21 d時(shí),模型組、蠲痹歷節(jié)清方組及別嘌醇組滑膜中血管數(shù)量均多于對(duì)照組(P=0.002,P=0.001,P=0.001; P=0.001,P=0.001,P=0.002; P=0.001,P=0.000,P=0.001; P=0.001,P=0.003,P=0.002); 藥物干預(yù)開始后7、14、21 d時(shí),蠲痹歷節(jié)清方組和別嘌醇組滑膜中血管數(shù)量均多于模型組(P=0.001,P=0.013; P=0.014,P=0.011; P=0.001,P=0.012); 其余各時(shí)點(diǎn)各組間兩兩比較,組間差異均無統(tǒng)計(jì)學(xué)意義。藥物干預(yù)開始后各時(shí)點(diǎn),4組動(dòng)物滑膜中中性粒細(xì)胞數(shù)量比較,組間差異均有統(tǒng)計(jì)學(xué)意義(F=32.347,P=0.001; F=43.561,P=0.001; F=42.361,P=0.014; F=51.745,P=0.011)。藥物干預(yù)開始后1、7、14 d時(shí),模型組、蠲痹歷節(jié)清方組及別嘌醇組滑膜中中性粒細(xì)胞數(shù)量均多于對(duì)照組(P=0.001,P=0.002,P=0.001; P=0.001,P=0.001,P=0.002; P=0.002,P=0.001,P= 0.001); 藥物干預(yù)開始后7、14 d時(shí),蠲痹歷節(jié)清方組和別嘌醇組滑膜中中性粒細(xì)胞數(shù)量均少于模型組(P=0.017,P=0.014; P=0.012,P=0.014); 藥物干預(yù)開始后21 d時(shí),對(duì)照組、蠲痹歷節(jié)清方組及別嘌醇組滑膜中中性粒細(xì)胞數(shù)量均少于模型組(P=0.001,P=0.013,P=0.017); 其余各時(shí)點(diǎn)各組間兩兩比較,組間差異均無統(tǒng)計(jì)學(xué)意義。結(jié)論:蠲痹歷節(jié)清方可通過抑制XOD活性,有效降低血尿酸水平,緩解雞急性痛風(fēng)性關(guān)節(jié)炎模型臨床癥狀,其療效與別嘌醇相當(dāng)。
Abstract:
Objective:Objective: To observe the effect of Juanbilijieqing Fang(蠲痹歷節(jié)清方)on acute gouty arthritis chiken model and to explore the mechanism of action.Methods:One hundred and sixty 30-day-old male XIANGHUANG chickens were randomly divided into control group,model group,Juanbilijieqing group and allopurinol group,40 cases in each group.The chickens in control group were fed with normal feedstuff,while the chickens in other groups were fed for consecutive 21 days with feedstuff which protein content was 50% to made into acute gouty arthritis models.After the end of the modeling,the chickens in Juanbilijieqing group and allopurinol group were intragastric administrated with Juanbilijieqing decoction and allopurinol solution respectively,while chickens in the other 2 groups were intragastric administrated with normal saline,twice a day for 21 consecutive days.Ten chickens were randomly selected from each group at 1,7,14 and 21 days after the beginning of drug intervention respectively; and the general state,ankle circumference,blood uric acid levels and serum xanthine oxidase(XOD)activity were observed respectively.Then the chickens were executed and the left ankle synovium were separated for observing the synovial tissue morphology under the optical microscope.Results:The chickens except those in control group became lethargic and their feathers became disorderly loose and matte and their eating and drinking began to decrease.Both knees and ankles began to swell up,and limping and unstable standing were found.White matters increased in feces.The general state of chickens in Juanbilijieqing group and allopurinol group basically returned to normal at 21 days after the beginning of the drug intervention.The chickens in model group improved in the general state,while their performance were worse than that of chickens in Juanbilijieqing group and allopurinol group.No change except increased body mass were found in the chickens in control group.No chickens died in each group during the modeling and experimental process.There was statistical difference in ankle circumference between the 4 groups at different timepoints after the beginning of the drug intervention(F=25.172,P=0.000; F=24.445,P=0.000; F=21.237,P=0.014; F=29.881,P=0.041).The ankle circumference was greater in model group,Juanbilijieqing group and allopurinol group compared with control group at 1,7 and 14 days after the beginning of the drug intervention(P=0.001,P=0.001,P=0.001; P=0.002,P=0.002,P=0.001; P=0.001,P=0.002,P=0.001).The ankle circumference was less in Juanbilijieqing group and allopurinol group compared with model group at 7 and 14 days after the beginning of the drug intervention(P=0.025,P=0.014; P=0.012,P=0.011).The ankle circumference was less in control group,Juanbilijieqing group and allopurinol group compared with model group at 21 days after the beginning of the drug intervention(P=0.001,P=0.015,P=0.013).There was no statistical difference in the ankle circumference between the paired groups at other timepoints.There was statistical difference in blood uric acid levels between the 4 groups at different timepoints after the beginning of the drug intervention(F=25.361,P=0.003; F=32.371,P=0.005; F=36.734,P=0.021; F=48.336,P=0.023).The blood uric acid levels were greater in model group,Juanbilijieqing group and allopurinol group compared with control group at 1,7 and 14 days after the beginning of the drug intervention(P=0.000,P=0.001,P=0.001; P=0.001,P=0.001,P=0.002; P=0.001,P=0.000,P=0.001).The blood uric acid levels were less in Juanbilijieqing group and allopurinol group compared with model group at 7 and 14 days after the beginning of the drug intervention(P=0.011,P=0.010; P=0.014,P=0.002).The blood uric acid levels were less in control group,Juanbilijieqing group and allopurinol group compared with model group at 21 days after the beginning of the drug intervention(P=0.001,P=0.012,P=0.011).There was no statistical difference in the blood uric acid levels between the paired groups at other timepoints.There was statistical difference in serum XOD activity between the 4 groups at different timepoints after the beginning of the drug intervention(F=45.721,P=0.001; F=50.634,P=0.002; F=49.448,P=0.013; F=63.124,P=0.027).The serum XOD activity was greater in model group,Juanbilijieqing group and allopurinol group compared with control group at 1,7 and 14 days after the beginning of the drug intervention(P=0.002,P=0.001,P=0.001; P=0.001,P=0.000,P=0.001; P=0.001,P=0.001,P=0.000).The serum XOD activity was less in Juanbilijieqing group and allopurinol group compared with model group at 7 and 14 days after the beginning of the drug intervention(P=0.001,P=0.013; P=0.002,P=0.015).The serum XOD activity was less in control group,Juanbilijieqing group and allopurinol group compared with model group at 21 days after the beginning of the drug intervention(P=0.001,P=0.013,P=0.017).There was no statistical difference in serum XOD activity between the paired groups at other timepoints.There was statistical difference in the number of blood vessels in synovium between the 4 groups at different timepoints after the beginning of the drug intervention(F=24.772,P=0.032; F=33.176,P=0.021; F=32.672,P=0.003; F=44.351,P=0.000).The number of blood vessels in synovium was more in model group,Juanbilijieqing group and allopurinol group compared with control group at 1,7,14 and 21 days after the beginning of the drug intervention(P=0.002,P=0.001,P=0.001; P=0.001,P=0.001,P=0.002; P=0.001,P=0.000,P=0.001; P=0.001,P=0.003,P=0.002).The number of blood vessels in synovium was more in Juanbilijieqing group and allopurinol group compared with model group at 7,14 and 21 days after the beginning of the drug intervention(P=0.001,P=0.013; P=0.014,P=0.011; P=0.001,P=0.012).There was no statistical difference in the number of blood vessels in synovium between the paired groups at other timepoints.There was statistical difference in the number of neutrophils in synovium between the 4 groups at different timepoints after the beginning of the drug intervention(F=32.347,P=0.001; F=43.561,P=0.001; F=42.361,P=0.014; F=51.745,P=0.011).The number of neutrophils in synovium was more in model group,Juanbilijieqing group and allopurinol group compared with control group at 1,7 and 14 days after the beginning of the drug intervention(P=0.001,P=0.002,P=0.001; P=0.001,P=0.001,P=0.002; P=0.002,P=0.001,P=0.001).The number of neutrophils in synovium was less in Juanbilijieqing group and allopurinol group compared with model group at 7 and 14 days after the beginning of the drug intervention(P=0.017,P=0.014; P=0.012,P=0.014).The number of neutrophils in synovium was less in control group,Juanbilijieqing group and allopurinol group compared with model group at 21 days after the beginning of the drug intervention(P=0.001,P=0.013,P=0.017).There was no statistical difference in the number of neutrophils in synovium between the paired groups at other timepoints.Conclusion:Juanbilijieqing Fang can effectively reduce the blood uric acid levels and relieve the clinical symptoms of acute gouty arthritis models through decreasing the activity of XOD,and it is similar to allopurinol in the curative effect.

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備注/Memo

備注/Memo:
2015-01-14收稿 2015-02-06修回
基金項(xiàng)目:湖南省自然科學(xué)基金(13JJ3102); 湖南省中醫(yī)藥管理局項(xiàng)目(201411)
通訊作者:熊輝 E-mail:[email protected]
更新日期/Last Update: 2015-03-30