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[1]李春雯.益氣溫經(jīng)法對絕經(jīng)后骨質(zhì)疏松性髖部骨折患者 骨轉(zhuǎn)換指標(biāo)的影響[J].中醫(yī)正骨,2014,26(12):7-9.
　Li Chunwen*.Effect of the therapeutic methods(TCM)of Reinforcing QI Warming Meridians on bone turnover indicators in patients with postmenopausal osteoporotic hip fracture[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(12):7-9.
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益氣溫經(jīng)法對絕經(jīng)后骨質(zhì)疏松性髖部骨折患者 骨轉(zhuǎn)換指標(biāo)的影響()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第26卷
期數(shù):
2014年12期
頁碼:
7-9
欄目:
臨床研究
出版日期:
2014-12-30

文章信息/Info

Title:
Effect of the therapeutic methods(TCM)of Reinforcing QI Warming Meridians on bone turnover indicators in patients with postmenopausal osteoporotic hip fracture
作者:
李春雯
浙江中醫(yī)藥大學(xué),浙江 杭州 310053
Author(s):
Li Chunwen*
Zhejiang Chinese Medical University,Hangzhou 310053,Zhejiang,China
關(guān)鍵詞:
骨質(zhì)疏松; 絕經(jīng)后 骨質(zhì)疏松性骨折 髖骨折 益氣 溫經(jīng) 強骨飲 骨密度 骨生成 骨吸收
Keywords:
Osteoporosis; postmenopausal;  Osteoporotic fractures;  Hip fractures;  Reinforcing QI;  Warming meridians;  Qianggu Yin;  Bone mineral density;  Osteogenesis;  Bone resorption
摘要:
目的:觀察益氣溫經(jīng)法對絕經(jīng)后骨質(zhì)疏松性髖部骨折患者骨形成和骨吸收指標(biāo)的影響。方法:將符合要求的75例絕經(jīng)后骨 質(zhì)疏松性單側(cè)髖部骨折患者隨機分為2組,中藥組37例、對照組38例。髖部骨折手術(shù)后,對照組口服鈣爾奇D片和阿法骨化醇膠囊, 每天1次,服用6個月,同時指導(dǎo)患者進(jìn)行規(guī)范的功能鍛煉; 中藥組在對照組用藥及功能鍛煉的基礎(chǔ)上口服強骨飲進(jìn)行治療,強骨飲 每天2次,服用6個月。分別于治療前和治療6個月后測定2組患者的骨密度、Ⅰ型膠原N前端肽和Ⅰ型膠原C末端肽血清含量。結(jié)果 :治療前2組患者腰椎骨密度比較,差異無統(tǒng)計學(xué)意義[(0.757±0.067)g·cm-2,(0.753±0.065) g·cm-2,t=0.297,P=0.767]; 治療6個月后,2組患者的腰椎骨密度均增大,中藥組骨密度的增加值大于對照組 [(0.018±0.025)g·cm-2,(0.005±0.027)g·cm-2,t=2.078,P=0.041]。治療前2組患者的Ⅰ 型膠原N前端肽和Ⅰ型膠原C末端肽血清含量比較,組間差異均無統(tǒng)計學(xué)意義[(46.27±9.35)ng·mL-1, (43.73±9.39)ng·mL-1,t=1.175,P=0.244;(0.577±0.236)ng·mL-1,(0.550±0.206)ng ·mL-1,t=0.530,P=0.598]; 治療6個月后中藥組患者的Ⅰ型膠原N前端肽和Ⅰ型膠原C末端肽血清含量均小于對照組 [(35.16±6.76)ng·mL-1,(46.61±9.04)ng·mL-1,t=6.198,P=0.000;(0.304±0.078)ng ·mL-1,(0.422±0.180)ng·mL-1,t=3.744,P=0.000]。結(jié)論:益氣溫經(jīng)法可通過降低Ⅰ型膠原N前 端肽和Ⅰ型膠原C末端肽的血清含量,抑制骨骼的高轉(zhuǎn)換狀態(tài),提高骨量,達(dá)到防治絕經(jīng)后骨質(zhì)疏松性髖部骨折的目的。
Abstract:
Objective:To observe the effect of the therapeutic methods(TCM)of Reinforcing QI Warming Meridians on bone turnover indicators in patients with postmenopausal osteoporotic hip fracture.Methods:Seventy-five patients with unilateral postmenopausal osteoporotic hip fracture enrolled in the study were randomly divided into traditional chinese medicine(TCM)group(37 cases)and control group(38 cases).The patients in control group were treated with oral application of Caltrate D tablets and Alfacalcidol capsules,once a day for consecutive 6 months.Meanwhile,normative functional exercises were performed with guidance from nurses.The patients in TCM group were treated with not only the same treatment but also oral application of Qianggu Yin(強骨飲)twice a day for consecutive 6 months.Bone mineral density(BMD)and serum concentrations of procollagenⅠN-terminal propeptide(PⅠNP)and collagen typeⅠC-terminal cross-linked telopeptide(CTX)were measured and compared between the 2 groups before treatment and after 6-month treatment respectively.Results:There was no statistical difference in lumbar vertebrae BMD between the 2 groups before the treatment(0.757+/-0.067 vs 0.753+/-0.065 g/cm(2),t=0.297,P=0.767),while the lumbar vertebrae BMD increased in both of the 2 groups after 6-month treatment and the increase value was greater in TCM group(0.018+/-0.025 vs 0.005+/-0.027 g/cm (2),t=2.078,P=0.041).There was no statistical difference in the serum concentrations of PⅠNP and CTX between the 2 groups before the treatment(46.27+/-9.35 vs 43.73+/-9.39 ng/ml,t=1.175,P=0.244; 0.577+/-0.236 vs 0.550+/-0.206 ng/ml,t=0.530,P=0.598),while the serum concentrations of PⅠNP and CTX were lower in the TCM group compared with the control group after 6-month treatment(35.16+/-6.76 vs 46.61+/-9.04 ng/ml,t=6.198,P=0.000; 0.304+/-0.078 vs 0.422+/-0.180 ng/ml,t=3.744,P=0.000).Conclusion:The therapeutic methods(TCM)of Reinforcing QI Warming Meridians can inhibit the high bone transition and increase bone mass by means of reducing the serum concentrations of PⅠNP and CTX,so it can prevent the postmenopausal osteoporotic hip fractures.

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備注/Memo

備注/Memo:
基金項目:2013年國家中醫(yī)藥行業(yè)科研專項項目(201307010); 2012年浙江省中醫(yī)藥重點項目(2012ZZ007)
通訊作者:李春雯 E-mail:[email protected]
更新日期/Last Update: 2014-12-30