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[1]孫德舜,王小鶴,王曉燕,等.自擬骨傷復(fù)元湯對(duì)胸腰椎骨折術(shù)后早期白介素-2、纖維蛋白原表達(dá)及疼痛的影響[J].中醫(yī)正骨,2014,26(08):8-11.
　Sun Deshun*,Wang Xiaohe,Wang Xiaoyan,et al.Effect of self-made GUSHANG FUYUAN DECOCTION on the early postoperative expression of interleukin-2 and fibrinogen and the pain in patients with thoracolumbar vertebral fracture[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(08):8-11.
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自擬骨傷復(fù)元湯對(duì)胸腰椎骨折術(shù)后早期白介素-2、纖維蛋白 原表達(dá)及疼痛的影響()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第26卷
期數(shù):
2014年08期
頁(yè)碼:
8-11
欄目:
臨床研究
出版日期:
2014-08-30

文章信息/Info

Title:
Effect of self-made GUSHANG FUYUAN DECOCTION on the early postoperative expression of interleukin-2 and fibrinogen and the pain in patients with thoracolumbar vertebral fracture
作者:
孫德舜; 王小鶴; 王曉燕; 宋義博; 王洪泰
山東省章丘市中醫(yī)醫(yī)院,山東 章丘 250200
Author(s):
Sun Deshun*; Wang Xiaohe; Wang Xiaoyan; Song Yibo; Wang Hongtai.
*Zhangqiu Hospital of Traditional Chinese Medicine,Zhangqiu 250200,Shandong,China
關(guān)鍵詞:
脊柱骨折 胸椎 腰椎 白介素-2 纖維蛋白原 骨傷復(fù)元湯
Keywords:
Spinal fracture;  Thoracic vertebrae;  Lumbar vertebrae;  Interleukin-2;  Fibrinogen;  GUSHANG FUYUAN DECOCTION
摘要:
目的:觀察自擬骨傷復(fù)元湯對(duì)胸腰椎骨折術(shù)后早期白介素-2、纖維蛋白原表達(dá)及患者疼痛的影響。方法:將符合要求的80例胸腰椎骨折患者隨機(jī)分為2組。對(duì)照組40例,術(shù)后給予補(bǔ)充血容量、抗感染等常規(guī)治療; 觀察組40例,術(shù)后給予常規(guī)治療聯(lián)合口服自擬骨傷復(fù)原湯治療。分別于術(shù)后第1天、第7天及第14天,比較2組患者血漿中白介素-2、纖維蛋白原含量的變化情況及疼痛視覺(jué)模擬評(píng)分變化情況。結(jié)果:①血漿白介素-2含量。不同時(shí)間點(diǎn)間血漿白介素-2的差異有統(tǒng)計(jì)學(xué)意義(F=98.792,P=0.000)。2組血漿白介素-2的組間差異總體上有統(tǒng)計(jì)學(xué)意義(F=18.916,P=0.000)。進(jìn)一步比較顯示,術(shù)后第1天2組患者血漿白介素-2含量的差異無(wú)統(tǒng)計(jì)學(xué)意義[(6.20±1.03)ng·L-1,(6.50±0.85)ng·L-1,t=-0.714,P=0.475]; 術(shù)后第7天、第14天2組患者血漿白介素-2含量比較,組間差異有統(tǒng)計(jì)學(xué)意義[(8.30±0.95)ng·L-1,(9.70±0.67)ng·L-1,t=-2.950,P=0.030;(10.20±1.32)ng·L-1,(11.90±1.29)ng·L-1,t=-2.431,P=0.015]; 時(shí)間因素與分組因素存在交互效應(yīng)(F=12.417,P=0.011)。②血漿纖維蛋白原含量。不同時(shí)間點(diǎn)間血漿纖維蛋白原含量的差異有統(tǒng)計(jì)學(xué)意義(F=118.439,P=0.000)。2組患者血漿纖維蛋白原含量的組間差異總體上有統(tǒng)計(jì)學(xué)意義(F=0.896,P=0.049)。進(jìn)一步比較顯示,術(shù)后第1天2組血漿纖維蛋白原含量比較,差異無(wú)統(tǒng)計(jì)學(xué)意義[(3.29±0.31)mg·dL-1,(3.34±0.23)mg·dL-1,t=0.277,P=0.741)]; 術(shù)后第7天、術(shù)后第14天,2組血漿纖維蛋白原含量比較,組間差異有統(tǒng)計(jì)學(xué)意義[(2.98±0.16)mg·dL-1,(2.39±0.18)mg·dL-1,t=1.487,P=0.042;(2.77±0.13)mg·dL-1,(2.11±0.12)mg·dL-1,t=8.952,P=0.039]; 時(shí)間因素與分組因素存在交互效應(yīng)(F=22.248,P=0.000)。③術(shù)后疼痛視覺(jué)模擬評(píng)分。不同時(shí)間點(diǎn)間術(shù)后疼痛視覺(jué)模擬評(píng)分的差異有統(tǒng)計(jì)學(xué)意義(F=264.972,P=0.000)。2組術(shù)后疼痛視覺(jué)模擬評(píng)分的組間差異總體上有統(tǒng)計(jì)學(xué)意義(F=6.399,P=0.039)。進(jìn)一步比較顯示,術(shù)后第1天2組術(shù)后疼痛視覺(jué)模擬評(píng)分的差異無(wú)統(tǒng)計(jì)學(xué)意義[(6.20±1.03)分,(6.10±0.99)分,t=0.221,P=0.828)]; 術(shù)后第7天、第14天,2組術(shù)后疼痛視覺(jué)模擬評(píng)分比較,組間差異有統(tǒng)計(jì)學(xué)意義[(3.70±1.06)分,(2.70±0.82)分,t=2.333,P=0.031;(2.00±0.82)分,(1.30±0.48)分,t=2.357,P=0.030]; 時(shí)間因素與分組因素存在交互效應(yīng)(F=12.662,P=0.024)。結(jié)論:在胸腰椎骨折患者術(shù)后早期應(yīng)用自擬骨傷復(fù)元湯,能夠提高血漿白介素-2的含量,降低纖維蛋白原的含量,有效緩解患者的疼痛。
Abstract:
Objective:To observe the effect of self-made GUSHANG FUYUAN DECOCTION on the early postoperative expression of interleukin-2 and fibrinogen and the pain in patients with thoracolumbar vertebral fracture.Methods:Eighty patients with thoracolumbar vertebral fracture enrolled in the study were randomly divided into 2 groups.The patients in control group(40 cases)were treated with postoperative conventional therapy including blood volume supplement and anti-infection drug after the surgery,while the others in observation group(40 cases)were treated with the conventional therapy combined with oral application of self-made GUSHANG FUYUAN DECOCTION.The plasma contents of interleukin-2 and fibrinogen and the visual analogue score(VAS)of pain were observed and compared between the 2 groups at the 1st,7th and 14th day after the operation respectively.Results:There was statistical difference in plasma interleukin-2 contents between different time points(F=98.792,P=0.000).There was statistical difference in the plasma interleukin-2 contents between the 2 groups(F=18.916,P=0.000).Further comparison indicated that there was no statistical difference in the plasma interleukin-2 contents between the 2 groups at the 1st day after the operation(6.20+/-1.03 vs 6.50+/-0.85 ng/L,t=-0.714,P=0.475).There was statistical difference in the plasma interleukin-2 contents between the 2 groups at the 7th and 14th day after the operation respectively(8.30+/-0.95 vs 9.70+/-0.67 ng/L,t=-2.950,P=0.030; 10.20+/-1.32 vs 11.90+/-1.29 ng/L,t=-2.431,P=0.015).There was interaction effect between time factor and grouping factor(F=12.417,P=0.011).There was statistical difference in plasma fibrinogen contents between different time points(F=118.439,P=0.000).There was statistical difference in the plasma fibrinogen content between the 2 groups(F=0.896,P=0.049).Further comparison indicated that there was no statistical difference in the plasma fibrinogen content between the 2 groups at the 1st day after the operation(3.29+/-0.31 vs 3.34+/-0.23 mg/dL,t=0.277,P=0.741).There was statistical difference in the plasma fibrinogen content between the 2 groups at the 7th and 14th day after the operation respectively(2.98+/-0.16 vs 2.39+/-0.18 mg/dL,t=1.487,P=0.042; 2.77+/-0.13 vs 2.11+/-0.12 mg/dL,t=8.952,P=0.039).There was interaction effect between time factor and grouping factor(F=22.248,P=0.000).There was statistical difference in the postoperative VAS between different time points(F=264.972,P=0.000).There was statistical difference in the postoperative VAS between the 2 groups(F=6.399,P=0.039).Further comparison indicated that there was no statistical difference in the postoperative VAS between the 2 groups at the 1st day after the operation(6.20+/-1.03 vs 6.10+/-0.99 points,t=0.221,P=0.828).There was statistical difference in the postoperative VAS between the 2 groups at the 7th and 14th day after the operation respectively(3.70+/-1.06 vs 2.70+/-0.82 points,t=2.333,P=0.031; 2.00+/-0.82 vs 1.30+/-0.48 points,t=2.357,P=0.030).There was interaction effect between time factor and grouping factor(F=12.662,P=0.024).Conclusion:The application of self-made GUSHANG FUYUAN DECOCTION can imcrease the plasma interleukin-2 contents and decrease the plasma fibrinogen contents and relieve the pain effectively in the early period after the surgery for patients with thoracolumbar vertebral fracture.

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備注/Memo

備注/Memo:
基金項(xiàng)目:山東省科技發(fā)展計(jì)劃立項(xiàng)課題(2013YD19008)
更新日期/Last Update: 2014-08-30