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[1]吳連國,劉康,黃俊俊,等.強骨飲對股骨頸骨折患者人工股骨頭置換術后假體周圍骨密度的影響[J].中醫(yī)正骨,2014,26(04):15-18.
　Wu Lianguo*,Liu Kang,Huang Junjun,et al.Effect of QIANGGU DRINK on peri-prosthetic bone density after artificial femoral head replacement in patients with femoral neck fractures[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(04):15-18.
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強骨飲對股骨頸骨折患者人工股骨頭置換術后假體周圍骨 密度的影響()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第26卷
期數(shù):
2014年04期
頁碼:
15-18
欄目:
臨床研究
出版日期:
2014-04-30

文章信息/Info

Title:
Effect of QIANGGU DRINK on peri-prosthetic bone density after artificial femoral head replacement in patients with femoral neck fractures
作者:
吳連國1; 劉康1; 黃俊俊1; 毛應德龍1; 陳華2; 史曉林1
1.浙江中醫(yī)藥大學附屬第二醫(yī)院,浙江 杭州 310005; 2.浙江中醫(yī)藥大學附屬第三醫(yī)院,浙江 杭州 310005
Author(s):
Wu Lianguo*; Liu Kang; Huang Junjun; Mao Yingdelong; Chen Hua; Shi Xiaolin.*
The Second Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine,Hangzhou 310005,Zhejiang,China
關鍵詞:
關節(jié)成形術; 置換; 髖 骨密度 股骨頸骨折 手術后并發(fā)癥 強骨飲
Keywords:
Arthroplasty; replacement; hip;  Bone density;  Femoral neck fractures;  Postoperative complications;  QIANGGU DRINK
摘要:
目的:探討強骨飲對股骨頸骨折患者人工股骨頭置換術后假體周圍骨密度的影響。方法:股骨頸骨折患者78例,按就診順序隨機分為觀察組和對照組,每組39例; 2組患者均進行人工股骨頭置換術,術后分別采用口服鈣爾奇D片和強骨飲及單純口服鈣爾奇D片進行干預。觀察2組患者術后髖關節(jié)功能恢復情況; 將人工假體柄周圍分為7個區(qū)(R1～R7),測量2組患者各區(qū)術后1周、術后3個月、術后6個月時假體周圍的骨密度,并進行比較。結果:78例患者均順利完成手術,74例獲得隨訪,觀察組失訪3例,對照組失訪1例; 隨訪時間9～24個月,中位數(shù)18.5個月; 患肢疼痛緩解、髖關節(jié)功能恢復。參照Harris髖關節(jié)評分標準對患肢髖關節(jié)進行評分,治療組(87.5±7.6)分,對照組(86.7±8.1)分,2組間差異無統(tǒng)計學意義(t=10.437,P=0.896)。均無假體松動等并發(fā)癥發(fā)生。R1區(qū),各時間點間骨密度值比較,差異有統(tǒng)計學意義(F=76.367,P=0.000),存在時間效應; 2組間骨密度值比較,差異有統(tǒng)計學意義(F=6.375,P=0.001),存在分組效應; 術后1周,2組間骨密度值比較,差異無統(tǒng)計學意義[(0.772±0.214)g·cm-2,(0.761±0.178)g·cm-2; t=0.578,P=0.683); 術后3個月、術后6個月,觀察組骨密度值均高于對照組[(0.758±0.268)g·cm-2,(0.602±0.244)g·cm-2; t=2.232,P=0.024;(0.732±0.227)g·cm-2,(0.518±0.188)g·cm-2; t=2.847,P=0.004)]; 時間因素和分組因素存在交互效應(F=36.726,P=0.000)。R2～R6區(qū)骨密度值 [R2:(1.532±0.342)g·cm-2,(1.478±0.451)g·cm-2,(1.432±0.403)g·cm-2;(1.613±0.268)g·cm-2,(1.582±0.265)g·cm-2,(1.533±0.275)g·cm-2。R3:(1.746±0.276)g·cm-2,(1.641±0.324)g·cm-2,(1.615±0.327)g·cm-2;(1.692±0.312)g·cm-2,(1.634±0.403)g·cm-2,(1.589±0.157)g·cm-2。R4:(1.831±0.302)g·cm-2,(1.768±0.256)g·cm-2,(1.711±0.236)g·cm-2;(1.798±0.275)g·cm-2,(1.735±0.358)g·cm-2,(1.636±0.326)g·cm-2。R5:(1.736±0.257)g·cm-2,(1.677±0.389)g·cm-2,(1.632±0.324)g·cm-2;(1.812±0.362)g·cm-2,(1.752±0.265)g·cm-2,(1.698±0.424)g·cm-2。R6:(1.563±0.352)g·cm-2,(1.612±0.327)g·cm-2,(1.578±0.367)g·cm-2;(1.642±0.279)g·cm-2,(1.598±0.278)g·cm-2(1.504±0.276)g·cm-2]各時間點間比較,差異均無統(tǒng)計學意義(F=2.468,P=0.162; F=1.569,P=0.453; F=1.862,P=0.358; F=3.556,P=0.112; F=4.065,P=0.104); 2組間比較,差異均無統(tǒng)計學意義(F=1.679,P=0.153; F=0.879,P=0.553; F=2.568,P=0.122; F=3.512,P=0.098; F=4.679,P=0.082); 時間因素和分組因素存在交互效應(F=26.765,P=0.000; F=23.343,P=0.000; F=28.276,P=0.000; F=21.825,P=0.000; F=26.468,P=0.000)。R7區(qū),各時間點間骨密度值比較,差異有統(tǒng)計學意義(F=52.828,P=0.000),存在時間效應; 2組間骨密度值比較,差異有統(tǒng)計學意義(F=12.476,P=0.000),存在分組效應; 術后1周,2組間骨密度值比較,差異無統(tǒng)計學意義[(1.292±0.262)g·cm-2,(1.203±0.322)g·cm-2; t=1.578,P=0.167]; 術后3個月、術后6個月,觀察組骨密度值均高于對照組[(1.178±0.345)g·cm-2,(0.869±0.159)g·cm-2; t=3.025,P=0.002;(1.123±0.312)g·cm-2,(0.752±0.328)g·cm-2; t=4.745,P=0.000]; 時間因素和分組因素存在交互效應(F=32.478,P=0.000)。結論:強骨飲可增加股骨頸骨折患者人工股骨頭置換術后股骨近端假體周圍的骨密度。
Abstract:
Objective:To study the effect of QIANGGU DRINK on peri-prosthetic bone density after artificial femoral head in patients with femoral neck fractures.Methods:Seventy-eight patients with femoral neck fractures were randomly divided into observation group and control group according to the visit sequence,39 cases in each group.All of the patients in the 2 groups were treated with artificial femoral head replacement,and then they were treated with oral application of caltrate D tablets combined with QIANGGU DRINK and monotherapy of oral application of caltrate D tablets respectively.Postoperative hip function restoration were reviewed and compared between the 2 groups.The areas around artificial prosthesis stem were divided into 7 zones(R1～R7)and the bone density was measured in each zone and compared between the 2 groups at 1 week and 3 and 6 months after the surgery.Results:The surgery were performed successfully in all the patients and 74 patients were available for follow-up.Three patients lost to follow-up in observation group and one patient lost to follow-up in control group.The median follow-up period was 18.5 years(range,9-24 months).The pain were relieved and the function of the hip joint were recovered in all the patients.The hip performance were evaluated according to the Harris Hip Score and the results showed that there was no statistical difference between the 2 groups(87.5+/-7.6 vs 86.7+/-8.1 points,t=10.437,P=0.896).No complications such as prosthesis loosening were found in the two groups.There was statistical difference in the bone density between different time points in R1 zone(F=76.367,P=0.000),in other words,there was time effect.There was statistical difference in the bone density between the 2 groups(F=6.375,P=0.001),in other words,there was group effect.There was no statistical difference in the bone density between the 2 groups one week after the surgery(0.772+/-0.214 vs 0.761+/-0.178 g/cm(2); t=0.578,P=0.683).The bone density of observation group were higher than those of control group 3 and 6 months after the surgery(0.758+/-0.268 vs 0.602+/-0.244 g/cm(2); t=2.232,P=0.024; 0.732+/-0.227 vs 0.518+/-0.188 g/cm(2); t=2.847,P=0.004).There was interaction between time factor and grouping factor(F=36.726,P=0.000).There was no statistical difference in the bone density of R2～R6 zones(R2:1.532+/-0.342,1.478+/-0.451,1.432+/-0.403 g/cm(2); 1.613+/-0.268,1.582+/-0.265,1.533+/-0.275 g/cm(2).R3:1.746+/-0.276,1.641+/-0.324,1.615+/-0.327 g·cm(2); 1.692+/-0.312,1.634+/-0.403,1.589+/-0.157 g/cm(2).R4:1.831+/-0.302,1.768+/-0.256,1.711+/-0.236 g/cm(2); 1.798+/-0.275,1.735+/-0.358,1.636+/-0.326 g/cm(2).R5:1.736+/-0.257,1.677+/-0.389,1.632+/-0.324 g/cm(2); 1.812+/-0.362,1.752+/-0.265,1.698+/-0.424 g/cm(2).R6:1.563+/-0.352,1.612+/-0.327,1.578+/-0.367 g/cm(2); 1.642+/-0.279,1.598+/-0.278,1.504+/-0.276 g/cm(2))between different time points(F=2.468,P=0.162; F=1.569,P=0.453; F=1.862,P=0.358; F=3.556,P=0.112; F=4.065,P=0.104).There was no statistical difference in the bone density between the 2 groups(F=1.679,P=0.153; F=0.879,P=0.553; F=2.568,P=0.122:F=3.512,P=0.098; F=4.679,P=0.082).There was interaction between time factor and grouping factor(F=26.765,P=0.000; F=23.343,P=0.000; F=28.276,P=0.000; F=21.825,P=0.000; F=26.468,P=0.000).There was statistical difference in the bone density between different time points in R7 zone(F=52.828,P=0.000),in other words,there was time effect.There was statistical difference in the bone density between the 2 groups(F=12.476,P=0.000),in other words,there was grouping effect.There was no statistical difference in the bone density between the 2 groups at one week after the surgery(1.292+/-0.262 vs 1.203+/-0.322 g/cm(2); t=1.578,P=0.167).The bone density of observation group were higher than those of control group at three and six months after the surgery(1.178+/-0.345 vs 0.869+/-0.159 g/cm(2); t=3.025,P=0.002; 1.123+/-0.312 vs 0.752+/-0.328 g/cm(2); t=4.745,P=0.000).There was interaction between time factor and grouping factor(F=32.478,P=0.000).Conclusion:QIANGGU DRINK can increase proximal femoral peri-prosthetic bone density after artificial femoral head replacement in patients with femoral neck fractures.

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備注/Memo

備注/Memo:
基金項目:中國博士后科學基金項目(2013M530290),國家中醫(yī)藥管理局2013年度中醫(yī)藥行業(yè)科研專項項目(201307010),浙江省自然科學基金資助項目(LY12H27013),浙江省醫(yī)壇新秀培養(yǎng)對象資助項目(浙衛(wèi)發(fā)2013-245號),浙江省博士后科研項目擇優(yōu)資助項目(BSH1302082),2013年浙江省醫(yī)藥衛(wèi)生科技計劃項目(2013KYA143)
更新日期/Last Update: 1900-01-01