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[1]孫艷,陳立忠,王海燕,等.增液潤節(jié)湯和美洛昔康片治療膝骨關(guān)節(jié)炎的對比研究[J].中醫(yī)正骨,2014,26(01):21-23.
　Sun Yan*,Chen Lizhong,Wang Haiyan,et al.A retrospective trial of ZENGYERUNJIE decoctions versus Meloxicam tablets in the treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(01):21-23.
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增液潤節(jié)湯和美洛昔康片治療膝骨關(guān)節(jié)炎的對比研究()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第26卷
期數(shù):
2014年01期
頁碼:
21-23
欄目:
骨關(guān)節(jié)炎
出版日期:
2014-01-28

文章信息/Info

Title:
A retrospective trial of ZENGYERUNJIE decoctions versus Meloxicam tablets in the treatment of knee osteoarthritis
作者:
孫艷; 陳立忠; 王海燕; 孫海東
中國人民解放軍第208醫(yī)院,吉林 長春 130062
Author(s):
Sun Yan*; Chen Lizhong; Wang Haiyan; Sun Haidong.
* The 208th hospital of PLA,Changchun 130062,Jilin,China
關(guān)鍵詞:
骨關(guān)節(jié)炎; 膝 消炎藥; 非甾類 治療; 臨床研究性 增液潤節(jié)湯
Keywords:
Osteoarthritis; knee;  Anti-inflammatory agents; non-steroidal;  Therapies; investigational;  ZENGYERUNJIE decoctions
摘要:
目的:對比增液潤節(jié)湯和美洛昔康片治療膝骨關(guān)節(jié)炎的臨床療效和安全性。方法:膝骨關(guān)節(jié)炎患者100例,隨機分為2組,每組50例。治療組口服增液潤節(jié)湯,對照組口服美洛昔康片,共治療2個月。觀察2組患者癥狀緩解、關(guān)節(jié)功能改善及不良反應(yīng)發(fā)生情況,并對2組患者的療效和不良反應(yīng)發(fā)生率進行比較。結(jié)果:治療前2組患者Lequesne指數(shù)評分比較,差異無統(tǒng)計學意義[(12.40±1.51)分,(11.85±1.75)分; t=1.683,P=0.097)]; 治療2個月后,2組患者癥狀緩解、患膝功能改善,Lequesne指數(shù)評分均下降,2組間比較差異有統(tǒng)計學意義[(6.82±1.64)分,(8.47±1.82)分; t=4.790,P=0.000]; 且治療組下降程度更明顯[(5.58±1.62)分,(3.38±1.36)分; t=7.355,P=0.000]。參照中藥新藥治療骨性關(guān)節(jié)炎的臨床研究指導原則中的療效判定標準評價療效,治療組臨床控制11例、顯效27例、有效11例、無效1例; 對照組臨床控制6例、顯效23例、有效12例、無效9例; 治療組療效優(yōu)于對照組,差異有統(tǒng)計學意義(Z=-2.338,P=0.019)。治療期間,治療組出現(xiàn)胃腸道反應(yīng)2例,肝功能異常1例; 對照組出現(xiàn)胃腸道反應(yīng)8例,心動過速2例,肝功能異常4例,白細胞下降2例,血肌酐增高3例。經(jīng)對癥處理后,2組患者不良反應(yīng)均消失。2組患者不良反應(yīng)發(fā)生率比較,差異有統(tǒng)計學意義(χ2=14.918,P=0.000)。結(jié)論:采用增液潤節(jié)湯和美洛昔康片治療膝骨關(guān)節(jié)炎,均可有效緩解癥狀、改善患膝功能; 但增液潤節(jié)湯療效優(yōu)于美洛昔康片,且不良反應(yīng)較少,更安全可靠。
Abstract:
Objective:To compare ZENGYERUNJIE decoctions and Meloxicam tablets in the clinical curative effects and safety for knee osteoarthritis(KOA).Methods:One hundred patients with KOA enrolled in the trial were randomly divided into 2 groups,50 cases in each group.Patients in treatment group were administrated with oral application of ZENGYERUNJIE decoctions,while the others in control group were administrated with oral application of Meloxicam tablets.The total disease course was 2 months.The symptoms relief,joint function improvement and adverse reactions were observed,and the curative effects and incidence rate of adverse reactions were compared between the 2 groups.Results:There was no statistical difference in the Lequesne indices scores between the 2 groups before the treatment(12.40+/-1.51 vs 11.85+/-1.75 points; t=1.683,P=0.097).After two-month treatment,the symptoms were relieved and the knee function were improved and the Lequesne indices scores decreased.There was statistical difference in Lequesne indices scores between the 2 groups(6.82+/-1.64 vs 8.47+/-1.82 points; t=4.790,P=0.000),and the decreased degree was bigger in treatment group compared to control group(5.58+/-1.62 vs 3.38+/-1.36 points,t=7.355,P=0.000).The curative effects were evaluated in accordance with the criterion in Guiding principles of clinical research on new Chinese medicine for osteoarthritis.Eleven patients got an excellent result,27 good,11 fair,and 1 poor in the treatment group,while 6 patients got an excellent result,23 good,12 fair,and 9 poor in the control group.The treatment group surpassed the control group in the clinical effect and there was statistical difference between the 2 groups(Z=-2.338,P=0.019).During the treatment,gastrointestinal reactions(2 patients)and transient liver dysfunction(1 patients)were found in the treatment group; while gastrointestinal reactions(8 patients),tachycardia(2 patients),transient liver dysfunction(4 patients),white blood cells(WBC)decrease(2 patients)and serum creatinine increase(3 patients)were found in the control group.Adverse reactions disappeared after symptomatic treatment in both of the 2 groups.There was statistical difference in incidence rate of adverse reaction between the 2 groups(χ2=14.918,P=0.000).Conclusion:In the treatment of KOA,oral application of both ZENGYERUNJIE decoctions and Meloxicam tablets can effectively relieve the symptoms and improve the knee function.However,the ZENGYERUNJIE decoctions surpassed the Meloxicam tablets in the clinical effect with less adverse reactions.

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更新日期/Last Update: 2014-01-20