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[1]王學(xué)宗,鄭昱新,曹月龍,等.柔肝和化痰中藥復(fù)方對膝骨關(guān)節(jié)炎患者關(guān)節(jié)功能及關(guān)節(jié)液軟骨寡聚基質(zhì)蛋白濃度的影響[J].中醫(yī)正骨,2014,26(01):17-20.
　Wang Xuezong*,Zheng Yuxin,Cao Yuelong,et al.Effect of nourishing liver compounds(TCD)and expelling phlegm compounds(TCD)on knee joint function and the synovial fluid concentration of cartilage oligomeric matrix protein in patients with knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(01):17-20.
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柔肝和化痰中藥復(fù)方對膝骨關(guān)節(jié)炎患者關(guān)節(jié)功能及關(guān)節(jié)液軟骨寡聚基質(zhì)蛋白濃度的影響()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第26卷
期數(shù):
2014年01期
頁碼:
17-20
欄目:
骨關(guān)節(jié)炎
出版日期:
2014-01-28

文章信息/Info

Title:
Effect of nourishing liver compounds(TCD)and expelling phlegm compounds(TCD)on knee joint function and the synovial fluid concentration of cartilage oligomeric matrix protein in patients with knee osteoarthritis
作者:
王學(xué)宗1; 鄭昱新1; 曹月龍2; 顧新豐1; 龐堅2; 詹紅生2
1.上海中醫(yī)藥大學(xué)附屬曙光醫(yī)院,上海 201203;
2.上海市中醫(yī)藥研究院骨傷科研究所,上海 201203
Author(s):
Wang Xuezong*; Zheng Yuxin; Cao Yuelong; Gu Xinfeng; Pang Jian; Zhan Hongsheng.
*Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China
關(guān)鍵詞:
骨關(guān)節(jié)炎; 膝 軟骨寡聚基質(zhì)蛋白 關(guān)節(jié)功能 柔肝 祛痰 治療; 臨床研究性
Keywords:
Osteoarthritis; knee;  Cartilage oligomeric matrix protein;  Joint function;  Nourishing liver;  Expelling phlegm;  Therapies; investigational
摘要:
目的:比較柔肝和化痰中藥復(fù)方對膝骨關(guān)節(jié)炎患者膝關(guān)節(jié)功能及關(guān)節(jié)液軟骨寡聚基質(zhì)蛋白濃度的影響及其安全性。方法:將61例符合要求的膝骨關(guān)節(jié)炎患者隨機(jī)分為2組,Ⅰ組32例,Ⅱ組29例。Ⅰ組患者口服柔肝中藥復(fù)方治療,Ⅱ組口服化痰中藥復(fù)方治療。分別于治療前和治療4周后采用酶聯(lián)免疫吸附法測定患者膝關(guān)節(jié)液中軟骨寡聚基質(zhì)蛋白的濃度,并采用自擬的膝關(guān)節(jié)功能評分量表評定患者的膝關(guān)節(jié)功能,同時觀察記錄2組患者治療期間的不良反應(yīng)發(fā)生情況。結(jié)果:①關(guān)節(jié)液COMP濃度測定結(jié)果。治療前2組患者膝關(guān)節(jié)液中軟骨寡聚基質(zhì)蛋白濃度比較,差異無統(tǒng)計學(xué)意義[(4.35±1.42)ng·mL-1,(4.77±1.74)ng·mL-1,t=1.437,P=0.601]; 治療后2組患者膝關(guān)節(jié)滑液中軟骨寡聚基質(zhì)蛋白濃度均降低[(4.21±1.66)ng·mL-1,(3.51±1.25)ng·mL-1],Ⅱ組降低程度更明顯[(0.35±0.12)ng·mL-1,(1.05±0.09)ng·mL-1,t=4.024,P=0.038]。②膝關(guān)節(jié)功能評定結(jié)果。治療前2組患者膝關(guān)節(jié)功能評分比較,差異無統(tǒng)計學(xué)意義[(20.63±4.89)分,(19.94±4.92)分,t=1.458,P=0.546]; 治療后2組患者膝關(guān)節(jié)功能評分均降低[(9.25±3.01)分,(9.13±2.83)分],2組治療前后降低程度比較,差異無統(tǒng)計學(xué)意義[(10.54±4.15)分,(9.97±4.07)分,t=1.913,P=0.205]。③不良反應(yīng)評定結(jié)果。2組患者治療期間均未發(fā)生與藥物相關(guān)的不良反應(yīng)。結(jié)論:與柔肝中藥復(fù)方相比,化痰中藥復(fù)方能更好地抑制膝骨關(guān)節(jié)炎患者軟骨寡聚基質(zhì)蛋白分泌,但二者改善膝關(guān)節(jié)功能的作用及其安全性相當(dāng)。
Abstract:
To compare nourishing liver compounds(TCD)with expelling phlegm compounds(TCD)in the safety and effect on knee joint function and the synovial fluid concentration of cartilage oligomeric matrix protein(COMP)in patients with knee osteoarthritis.Methods:Sixty-one patients with knee osteoarthritis were included into the study and were randomly divided into 2 groups,32 patients in groupⅠwere administrated with nourishing liver compounds(TCD),while the others in groupⅡwere administrated with expelling phlegm compounds(TCD).The synovial fluid concentration of COMP were detected by enzyme-linked immunosorbent assay before the treatment and 4 weeks after the treatment respectively,and the knee joint functions were evaluated according to the self-designed knee joint function scale.Meantime,the adverse reactions were observed and recorded.Results:There was no statistical difference in the concentration of COMP in synovial fluid between the 2 groups before the treatment(4.35+/-1.42 vs 4.77+/-1.74 ng/mL,t=1.437,P=0.601),while the COMP concentration decreased in both of the 2 groups after the treatment,and the COMP concentration decreased more significantly in the groupⅡ(0.35+/-0.12 vs 1.05+/-0.09 ng/mL,t=4.024,P=0.038).There was no statistical difference in knee joint functional scores between the 2 groups before the treatment(20.63+/-4.89 vs 19.94+/-4.92 points,t=1.458,P=0.546),while the knee joint function scores decreased in both of the 2 groups after the treatment(9.25+/-3.01 vs 9.13+/-2.83 points),and there was no statistical difference between the 2 groups in the degree of decrease in knee joint function scores(10.54+/-4.15 vs 9.97+/-4.07 points,t=1.913,P=0.205).No adverse reactions related to drugs were found during the treatment in both of the 2 groups.Conclusion:For patients with knee osteoarthritis,nourishing liver compounds(TCD)and expelling phlegm compounds(TCD)have similar effects in improving the knee joint function,and they are similar to each other in safety,while the latter is more helpful to inhibit the secretion of COMP.

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備注/Memo

備注/Memo:
基金項目:國家十一五支撐計劃項目(2007BAI20B033),“中醫(yī)骨傷科學(xué)”國家重點學(xué)科項目(100508),“海派中醫(yī)流派傳承研究基地”項目(ZYSNXD-CC-HPGC-JD-001),上海市教委項目(08cz025),上海市科委重點科技攻關(guān)項目(11DZ1972902)
通訊作者:鄭昱新 E-mail:[email protected]
更新日期/Last Update: 2014-01-20