84年鼠女哪年财运最旺,857comvvv色九欧美激情|85PO_87国产精品欲av国产av资源

[1]項旻,楊虹,林愛菊,等.絕經(jīng)后2型糖尿病患者骨質(zhì)疏松與血微量元素的關(guān)系研究[J].中醫(yī)正骨,2013,25(12):20-23.
　Xiang Min*,Yang Hong,Lin Aiju,et al.Clinical study on the relationship between osteoporosis and serum trace elements levels in postmenopausal women with type 2 diabetes[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(12):20-23.
點擊復(fù)制

絕經(jīng)后2型糖尿病患者骨質(zhì)疏松與血微量元素的關(guān)系研究()
分享到：

《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第25卷
期數(shù):
2013年12期
頁碼:
20-23
欄目:
骨質(zhì)疏松癥
出版日期:
2013-12-30

文章信息/Info

Title:
Clinical study on the relationship between osteoporosis and serum trace elements levels in postmenopausal women with type 2 diabetes
作者:
項旻; 楊虹; 林愛菊; 閆紹榮; 葉成夫; 盧學(xué)勉
溫州醫(yī)科大學(xué)附屬第三醫(yī)院,浙江 瑞安 325200
Author(s):
Xiang Min*; Yang Hong; Lin Aiju; Yan Shaorong; Ye Chengfu; Lu Xuemian.*
The Third Affiliated Hospital of Wenzhou Medical University,Ruian 325200,Zhejiang,China
關(guān)鍵詞:
骨質(zhì)疏松; 絕經(jīng)后 糖尿病; 2型 骨密度 微量元素
Keywords:
Osteoporosis; postmenopausal;  Diabetes mellitus; type 2;  Bone density;  Trace elements
摘要:
目的:探討絕經(jīng)后2型糖尿病患者骨質(zhì)疏松與血微量元素間的關(guān)系。方法:納入絕經(jīng)后女性168例,年齡48～82歲,中位數(shù) 63.5歲; 其中2型糖尿病患者122例,健康女性46例。所有受檢者均測定血清鈣、鎂、鋅、銅、鐵含量和糖化血紅蛋白含量,并測 定身高和體質(zhì)量。絕經(jīng)后2型糖尿病患者同時測定腰椎和左側(cè)股骨骨密度。將絕經(jīng)后2型糖尿病患者納入Ⅰ組,絕經(jīng)后健康女性納 入Ⅱ組,比較2組受檢者微量元素的血清含量。根據(jù)骨密度檢測結(jié)果,將122例絕經(jīng)后2型糖尿病患者中骨密度正常者納入A組、骨 量減少者納入B組、骨質(zhì)疏松者納入C組,比較3組患者微量元素的血清含量; 然后根據(jù)是否骨質(zhì)疏松將122例絕經(jīng)后2型糖尿病患 者分為2組,采用Logistic回歸分析法分析絕經(jīng)后2型糖尿病患者骨質(zhì)疏松與血微量元素的關(guān)系。結(jié)果:①絕經(jīng)后2型糖尿病與血微 量元素的關(guān)系。Ⅰ組受檢者血液中鋅、鎂含量低于Ⅱ組[(91.42±10.88)μmol·L-1,(98.47±11.06) μmol·L-1,t=15.890,P=0.000;(1.46±0.14)mmol·L-1,(1.69±0.14)mmol·L- 1,t=88.490,P=0.000]; 銅、鈣、鐵含量與Ⅱ組比較,差異無統(tǒng)計學(xué)意義[(12.95±2.43)μmol·L-1, (12.54±2.11)μmol·L-1,t=1.053,P=0.306;(1.52±0.13)mmol·L-1,(1.54±0.15) mmol·L-1,t=0.890,P=0.347;(8.07±1.16)mmol·L-1,(8.17±1.40)mmol·L- 1,t=0.968,P=0.323]。②絕經(jīng)后2型糖尿病患者骨質(zhì)疏松與血微量元素的關(guān)系。A組42例,B組40例,C組40例。3組絕經(jīng)后2 型糖尿病患者血液中鈣、鎂、鐵含量比較,組間差異無統(tǒng)計學(xué)意義[(1.53±0.10)mmol·L-1, (1.51±0.17)mmol·L-1,(1.50±0.12)mmol·L-1,F=0.362,P=0.697;(1.47±0.13)mmol ·L-1,(1.45±0.15)mmol·L-1,(1.44±0.14)mmol·L-1,F=0.325,P=0.723; (8.39±1.11)mmol·L-1,(7.94±1.28)mmol·L-1,(7.90±1.04)mmol·L- 1,F=2.324,P=0.102]。銅、鋅含量比較,組間差異有統(tǒng)計學(xué)意義[(13.99±2.33)μmol·L-1, (12.83±1.89)μmol·L-1,(12.09±2.64)μmol·L-1,F=7.027,P=0.001; (96.80±11.09)μmol·L-1,(91.51±9.64)μmol·L-1,(86.21±9.39)μmol·L- 1,F=11.388,P=0.000]。A組患者血液中銅含量高于B組和C組(P=0.027,P=0.000),B、C組比較,差異無統(tǒng)計學(xué)意義 (P=0.149); A組患者血液中鋅含量高于B組和C組(P=0.020,P=0.000),B組高于C組(P=0.018)。對血液中鋅、銅、鈣、鎂、鐵含量 行二元Logistic回歸分析顯示,血液中銅、鋅含量為絕經(jīng)后2型糖尿病患者骨質(zhì)疏松的保護(hù)因素(OR=0.731,P=0.006; OR=0.843,P=0.046)。結(jié)論:絕經(jīng)后2型糖尿病患者骨質(zhì)疏松與血液中鋅、銅缺乏有關(guān)。
Abstract:
Objective:To explore the relationship between osteoporosis and serum trace elements levels in postmenopausal women with type 2 diabetes.Methods:One hundred and sixty-eight postmenopausal women were recruited.The subjects consisted of 122 women with type 2 diabetes(groupⅠ)and 46 healthy women(groupⅡ),and ranged in age from 48 to 82 years(Median=63.5 yrs).The serum level of calcium,magnesium,zinc,copper,iron and glycosylated hemoglobin were detected,and the body height and body mass were measured for all the subjects.The serum level of trace elements were compared between the two groups.Meanwhile,the bone mineral density(BMD)of lumbar vertebrae and left femur were detected in groupⅠ.According to the BMD,the women in groupⅠwere divided into 3 subgroups.The women with normal BMD were recruited into group A,lower BMD women were recruited into group B,while the osteoporotic women were recruited into group C.The serum level of trace elements were compared between the three subgroups.Furthermore,the women in groupⅠwere divided into osteoporosis subgroup and non-osteoporosis subgroup,and the relationship between osteoporosis and serum trace elements levels in postmenopausal women with type 2 diabetes was analyzed through logistic regression analysis.Results:The serum content of zinc and magnesium of groupⅠwere lower than those of groupⅡ(91.42+/-10.88 vs 98.47+/-11.06 μmol/L,t=15.890,P=0.000; 1.46 +/-0.14 vs 1.69+/-0.14 mmol/L,t=88.490,P=0.000).There were no statistical differences in the serum content of copper,calcium and iron between the 2 groups(12.95+/-2.43 vs 12.54+/-2.11 μmol/L,t=1.053,P=0.306; 1.52+/-0.13 vs 1.54+/-0.15 mmol/L,t=0.890,P=0.347; 8.07+/-1.16 vs 8.17+/-1.40 mmol/L,t=0.968,P=0.323).Among the 122 women with type 2 diabetes,42 cases were included into group A,40 cases in group B,40 cases in group C.There were no statistical differences in the serum content of calcium,magnesium and iron among the 3 subgroups(1.53+/- 0.10,1.51+/-0.17,1.50+/-0.12 mmol/L,F=0.362,P=0.697; 1.47+/-0.13,1.45+/-0.15,1.44+/-0.14 mmol/L,F=0.325,P=0.723; 8.39+/-1.11,7.94+/-1.28,7.90+/-1.04 mmol/L,F=2.324,P=0.102).There were statistical differences in the serum content of copper and zinc among the 3 subgroups(13.99+/-2.33,12.83+/-1.89,12.09+/- 2.64 μmol/L,F=7.027,P=0.001; 96.80+/-11.09,91.51+/-9.64,86.21+/-9.39 μmol/L,F=11.388,P=0.000).The serum copper content of group A was higher than that of group B and group C(P=0.027,P=0.000),and there was no statistical differences between group B and group C(P=0.149).The serum zinc content of group A was higher than that of group B and group C(P=0.020,P=0.000),and group B surpassed group C(P=0.018).The results of logistic regression analysis showed that the serum content of copper and zinc was the protective factor for osteoporosis of postmenopausal women with type 2 diabetes(OR=0.731,P=0.006; OR=0.843,P=0.046).Conclusion:The osteoporosis may be associated with lack of serum zinc and serum copper for postmenopausal women with type 2 diabetes.

參考文獻(xiàn)/References:

[1] 常小霞,吳潔,任慕蘭.微量元素與絕經(jīng)后骨質(zhì)疏松癥[J].中國骨質(zhì)疏松雜志,2006,12(6):635-638.
[2] 葉任高,陸再英.內(nèi)科學(xué)[M].5版.北京:人民衛(wèi)生出版社,2001:887.
[3] Quraishi I,Collins S,Pestaner JP,et al.Role of zinc and zinc transporters in the molecular pathogenesis of diabetes mellitus[J].Med Hypotheses,2005,65(5):887-892.
[4] 蔡露,李才.微量元素鋅與糖尿病[M].北京:科學(xué)出版社,2010:9-10.
[5] 周建烈,陳聲.骨質(zhì)疏松性骨折防治新概念:補充韌骨元素鎂、鋅、銅、錳[J].中國骨質(zhì)疏松雜志,2012,18(12):1145-1153.
[6] 張克民,李偉,于立志,等.不同類型的骨質(zhì)疏松患者銅元素含量研究[J].山東醫(yī)藥,2011,51(44):80-81.
[7] 王麗暉,孫立娟,李艷華,等.血鎂水平與2型糖尿病及糖尿病腎病的相關(guān)性[J].中國老年學(xué)雜志,2013,33(5):1018-1020.
[8] 李萬里,田玉慧,卜勇軍,等.老年婦女膳食營養(yǎng)素與骨密度相關(guān)因素研究[J].實用預(yù)防醫(yī)學(xué),2002,9(6):586-587.

相似文獻(xiàn)/References:

[1]李林軍.應(yīng)用膨脹式椎弓根螺釘內(nèi)固定治療合并骨質(zhì)疏松的 胸腰椎退行性疾病[J].中醫(yī)正骨,2015,27(08):49.
[2]韓艷,溫利平,劉娜,等.補腎活血方對去卵巢大鼠骨代謝及骨密度的影響[J].中醫(yī)正骨,2015,27(12):7.
　HAN Yan,WEN Liping,LIU Na,et al.Effect of Bushen Huoxue Fang(補腎活血方)on bone metabolism and bone mineral density in the ovariectomized rats[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(12):7.
[3]李學(xué)朋,朱立國.骨疏康膠囊對去卵巢大鼠骨小梁的影響[J].中醫(yī)正骨,2015,27(12):12.
　LI Xuepeng,ZHU Liguo.Effect of Gushukang Jiaonang(骨疏康膠囊)on bone trabecula in the ovariectomized rats[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(12):12.
[4]陳冠軍,陳揚,莊汝杰.可灌注骨水泥椎弓根螺釘系統(tǒng) 在老年腰椎疾患手術(shù)中的應(yīng)用[J].中醫(yī)正骨,2015,27(02):40.
[5]王丹輝,賁越,韓梅.林蛙油治療絕經(jīng)后骨質(zhì)疏松癥的臨床研究[J].中醫(yī)正骨,2014,26(01):27.
　Wang Danhui*,Ben Yue,Han Mei..Clinical study of Rana temporaria oil in the treatment of postmenopausal osteoporosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(12):27.
[6]黃建華,黃建武,李慧輝,等.加味左歸丸對絕經(jīng)后骨質(zhì)疏松癥肝腎不足證 患者骨密度的影響[J].中醫(yī)正骨,2013,25(11):19.
　Huang Jianhua*,Huang Jianwu,Li Huihui,et al.Effect of JIAWEI ZUOGUI pill on bone mineral density in postmenopausal osteoporosis patients with deficiency of liver and kidney[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(12):19.
[7]史曉林,李春雯,張志強.弱陽離子磁珠分離技術(shù)和基質(zhì)輔助激光解吸電離飛行時間質(zhì)譜技術(shù)在原發(fā)性Ⅰ型骨質(zhì)疏松癥血清標(biāo)志蛋白篩選中的應(yīng)用[J].中醫(yī)正骨,2014,26(03):5.
　Shi Xiaolin*,Li Chunwen,Zhang Zhiqiang..Application of magnetic beads based weak cation exchange separation technology and matrix-assisted laser desorption-ionization time of flight mass spectrometry technology in screening serum protein markers of primary type-Ⅰ osteoporosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(12):5.
[8]李明,徐明雄,馮左基,等.自擬壯骨方治療絕經(jīng)后骨質(zhì)疏松癥的療效及作用機制研究[J].中醫(yī)正骨,2014,26(09):21.
　Li Ming*,Xu Mingxiong,Feng Zuoji,et al.Study on the curative effect and mechanism of action of self-made ZHUANGGU decoction in treatment of postmenopausal osteoporosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2014,26(12):21.
[9]陳俊杰,李晴晴,夏瑢.脂代謝及血清內(nèi)脂素水平與絕經(jīng)后骨質(zhì)疏松癥的 相關(guān)性研究[J].中醫(yī)正骨,2012,24(04):16.
　CHEN Jun-jie*,LI Qing-qing,XIA Rong.*.Study on the correlations between the levels of lipid metabolism and serum visfatin and postmenopausal osteoporosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2012,24(12):16.
[10]許超,肖魯偉,吳承亮.絕經(jīng)后女性骨質(zhì)疏松癥辨證分型與抑郁焦慮的關(guān)系研究[J].中醫(yī)正骨,2011,23(12):3.
　XU Chao*,XIAO Lu-wei,WU Cheng-liang.*.Study on the relationship between the syndrome differ classification and the depression and anxiety for the postmenopausal women with osteoporosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2011,23(12):3.

備注/Memo

備注/Memo:
2013-09-06收稿 2013-10-20修回
基金項目:浙江省瑞安市科技局基金項目(201302030)
更新日期/Last Update: 2013-12-30