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[1]譚勇海,姜苗苗,于海勇,等.關(guān)節(jié)鏡清理聯(lián)合自體骨髓間充質(zhì)干細(xì)胞移植治療 膝骨關(guān)節(jié)炎的療效觀察[J].中醫(yī)正骨,2013,25(10):35-38.
　Tan Yonghai*,Jiang Miaomiao,Yu Haiyong,et al.Therapeutic effect of arthroscopy combined with autologous bone marrow stem cell grafting on knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(10):35-38.
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關(guān)節(jié)鏡清理聯(lián)合自體骨髓間充質(zhì)干細(xì)胞移植治療 膝骨關(guān)節(jié)炎的療效觀察()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第25卷
期數(shù):
2013年10期
頁(yè)碼:
35-38
欄目:
臨床研究
出版日期:
2013-10-30

文章信息/Info

Title:
Therapeutic effect of arthroscopy combined with autologous bone marrow stem cell grafting on knee osteoarthritis
作者:
譚勇海; 姜苗苗; 于海勇; 李佳林; 苘志英
山東省文登整骨醫(yī)院,山東 文登 264400
Author(s):
Tan Yonghai*; Jiang Miaomiao; Yu Haiyong; Li Jialin; Qing Zhiying.*
The Wendeng Osteopath Hospital,Wendeng 264400,Shandong,China
關(guān)鍵詞:
骨關(guān)節(jié)炎; 膝 關(guān)節(jié)鏡檢查 骨髓移植 間質(zhì)干細(xì)胞移植 治療; 臨床研究性
Keywords:
Osteoarthritis; knee;  Arthroscopy;  Bone marrow transplantation;  Mesenchymal stem cell transplantation;  Therapies; investigational
摘要:
目的:觀察關(guān)節(jié)鏡清理聯(lián)合自體骨髓間充質(zhì)干細(xì)胞移植治療膝骨關(guān)節(jié)炎的臨床療效。方法:將符合要求的72例膝骨關(guān)節(jié)炎患者隨機(jī)分為治療組和對(duì)照組,每組36例。治療組采用關(guān)節(jié)鏡清理聯(lián)合自體骨髓干細(xì)胞移植治療,對(duì)照組僅采用關(guān)節(jié)鏡清理治療。分別于治療前和關(guān)節(jié)鏡清理術(shù)后12個(gè)月采用磁共振成像掃描儀測(cè)定患者膝關(guān)節(jié)軟骨厚度,并采用Lequesne骨關(guān)節(jié)炎嚴(yán)重程度和病情活動(dòng)指數(shù)評(píng)定患者的膝關(guān)節(jié)功能。結(jié)果:①膝關(guān)節(jié)軟骨厚度。治療前2組患者膝關(guān)節(jié)軟骨厚度比較,差異無統(tǒng)計(jì)學(xué)意義[(3.80±0.24)mm,(3.85±0.23)mm,t=0.576,P=0.793]; 關(guān)節(jié)鏡清理術(shù)后12個(gè)月,治療組膝關(guān)節(jié)軟骨厚度增加[(4.60±0.15)mm,t=53.748,P=0.000],對(duì)照組膝關(guān)節(jié)軟骨厚度與治療前相比,差異無統(tǒng)計(jì)學(xué)意義[(3.75±0.26)mm,t=0.712,P=0.365]; 治療組關(guān)節(jié)鏡清理術(shù)后12個(gè)月與治療前膝關(guān)節(jié)軟骨厚度的差值大于對(duì)照組[(1.06±0.16)mm,(0.46±0.08)mm,t=3.486,P=0.000]。②Lequesne指數(shù)。治療前2組患者Lequesne指數(shù)比較,差異無統(tǒng)計(jì)學(xué)意義[(19.72±1.34),(19.86±1.58),t=0.278,P=0.638]; 關(guān)節(jié)鏡清理術(shù)后12個(gè)月,2組患者膝關(guān)節(jié)Lequesne指數(shù)均減小[(5.19±1.12),t=25.894,P=0.000;(10.42±1.08),t=5.427,P=0.000],治療組減小更明顯[(14.28±1.16),(8.96±1.38),t=5.879,P=0.000]。結(jié)論:關(guān)節(jié)鏡清理聯(lián)合自體骨髓間充質(zhì)干細(xì)胞移植可明顯增加膝骨關(guān)節(jié)炎患者的膝關(guān)節(jié)軟骨厚度,有效改善膝關(guān)節(jié)功能,是治療膝骨關(guān)節(jié)炎的有效方法。
Abstract:
Objective:To observe the therapeutic effect of arthroscopy combined with autologous bone marrow stem cell(BMSC)grafting on knee osteoarthritis(KOA).Methods:Seventy-two patients with KOA enrolled in the study were randomly divided into treatment group and control group,36 cases in each group.Patients in treatment group were treated with arthroscopy combined with autologous BMSC grafting,while the others in control group were treated with arthroscopy.Magnetic resonance imaging(MRI)were performed and the thickness of knee articular cartilage were measured in all patients before treatment and 12 months after arthroscopy respectively.The knee joint function was assessed by using the indices of severity and disease activity for osteoarthritis.Results:There was no statistical difference in the thickness of knee articular cartilage between the 2 groups before the treatment(3.80+/-0.24 vs 3.85+/-0.23 mm,t=0.576,P=0.793).The thickness of knee articular cartilage increased in treatment group 12 months after arthroscopy(4.60+/-0.15 mm,t=53.748,P=0.000),and there was no statistical difference in the thickness of knee articular cartilage between pre-treatment and post-treatment in control group(3.75+/-0.26 mm,t=0.712,P=0.365).The differences between pre-treatment and post-treatment of treatment group were larger than that of control group in the thickness of knee articular cartilage(1.06+/-0.16 vs 0.46+/-0.08 mm,t=3.486,P=0.000).There was no statistical difference in the Lequesne indices between the 2 groups before the treatment(19.72+/-1.34 vs 19.86+/-1.58,t=0.278,P=0.638).The Lequesne indices of the 2 groups declined 12 months after arthroscopy(5.19+/-1.12,t=25.894,P=0.000; 10.42+/-1.08,t=5.427,P=0.000),and there was a bigger decline in treatment group compared to control group(14.28+/-1.16 vs 8.96+/-1.38,t=5.879,P=0.000).Conclusion:The therapy of arthroscopy combined with autologous BMSC grafting performs well on KOA for obvious increase in the thickness of knee articular cartilage and improvement in knee joint functions.

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備注/Memo

備注/Memo:
2012-07-02收稿 2012-09-03修回
更新日期/Last Update: 2013-10-30