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[1]高廣凌,黃相杰,姜紅江,等.接骨藥丸防治人工股骨頭置換術(shù)后 假體周圍骨質(zhì)疏松的療效觀察[J].中醫(yī)正骨,2013,25(09):19-21.
　Gao Guangling*,Huang Xiangjie,Jiang Hongjiang,et al.Evaluation of the preventative effect of JIEGUYAO pill on periprosthetic osteoporosis after hip hemiarthroplasty[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(09):19-21.
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接骨藥丸防治人工股骨頭置換術(shù)后 假體周圍骨質(zhì)疏松的療效觀察()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第25卷
期數(shù):
2013年09期
頁碼:
19-21
欄目:
臨床研究
出版日期:
2013-09-30

文章信息/Info

Title:
Evaluation of the preventative effect of JIEGUYAO pill on periprosthetic osteoporosis after hip hemiarthroplasty
作者:
高廣凌; 黃相杰; 姜紅江; 焦明航; 王亮
山東省文登整骨醫(yī)院,山東 文登 264400
Author(s):
Gao Guangling*; Huang Xiangjie; Jiang Hongjiang; Jiao Minghang; Wang Liang.*
The Wendeng Osteopath Hospital,Wendeng 264400, Shandong,China
關(guān)鍵詞:
骨質(zhì)疏松 接骨藥丸 關(guān)節(jié)成形術(shù); 置換; 髖 治療; 臨床研究性
Keywords:
Osteoporosis;  JIEGUYAO pill;  Arthroplasty; replacement; hip;  Therapies; investigational
摘要:
目的:觀察接骨藥丸防治人工股骨頭置換術(shù)后假體周圍骨質(zhì)疏松的臨床療效。方法:將72例需行人工股骨頭置換術(shù)的股骨 頸骨折患者隨機(jī)分為2組,每組36例。人工股骨頭置換術(shù)后,治療組患者口服接骨藥丸治療,連續(xù)服用2個月; 對照組患者口服活性 維生素D治療,連續(xù)服用2個月。分別于服藥前和服藥2個月后測定2組患者的股骨骨密度、血清堿性磷酸酶含量及疼痛程度分級, 并根據(jù)以上3個指標(biāo)制定療效評定標(biāo)準(zhǔn),評定患者的臨床綜合療效。結(jié)果:①骨密度。治療前2組患者骨密度比較,差異無統(tǒng)計學(xué)意 義(t=-0.079,P=0.937); 治療后2組患者骨密度均增高[(0.449±0.060)g·cm-2,(0.544±0.072) g·cm-2,t=8.638,P=0.000;(0.450±0.058)g·cm-2,(0.507±0.069)g·cm- 2,t=6.107,P=0.000],治療組增高更明顯[(0.095±0.066)g·cm-2,(0.057±0.056)g·cm- 2,t=2.654,P=0.038]。②血清堿性磷酸酶含量。治療前2組患者血清堿性磷酸酶含量比較,差異無統(tǒng)計學(xué)意義(t=- 0.135,P=0.893); 治療后2組患者血清堿性磷酸酶含量均增高[(8.080±0.498)μg·L-1,(9.090±0.452) μg·L-1,t=9.770,P=0.000;(8.096±0.500)μg·L-1,(8.644±0.408)μg·L- 1,t=6.495,P=0.000],治療組增高更明顯[(1.010±0.618)μg·L-1,(0.549±0.507)μg·L- 1,t=3.463,P=0.001]。③臨床綜合療效。治療組顯效12例、有效22例、無效2例,對照組顯效6例、有效21例、無效9例,治 療組臨床綜合療效優(yōu)于對照組( 治療組=31.33, 對照組=41.67,Z=-2.390,P=0.017)。結(jié)論:接骨藥丸可明顯提高股骨頭置換術(shù)后 患者股骨骨密度和血清堿性磷酸酶含量,防治假體周圍骨質(zhì)疏松的療效優(yōu)于活性維生素D。
Abstract:
Objective:To observe the curative effect of JIEGUYAO pill in the prevention of periprosthetic osteoporosis after hip hemiarthroplasty.Methods:Seventy-two patients with femoral neck fracture who needed hip hemiarthroplasty were randomly divided into treatment group and control group,36 cases in each group.After the operation,the patients in treatment group were administered with JIEGUYAO pills for 2 months,while the others in control group were administered with activated vitamin D for 2 months.Femoral bone mineral density (BMD),alkaline phosphatase(ALP)contents and pain degrees were determined before and after the treatment.Based on the determination results,the total clinical curative effects were evaluated according to the self-designed evaluation standard.Results:There was no statistical difference in the femoral BMD between the 2 groups before the treatment(t=-0.079,P=0.937); while the femoral BMD increased in both of the 2 groups after the treatment (0.449+/-0.060 vs 0.544+/-0.072 g/cm(2),t=8.638,P=0.000; 0.450+/-0.058 vs 0.507+/-0.069 g/cm (2),t=6.107,P=0.000),and the femoral BMD increased more significantly in the treatment group(0.095+/-0.066 vs 0.057+/-0.056 g/cm(2),t=2.654,P=0.038).There was no statistical difference in the ALP contents between the 2 groups before the treatment(t=-0.135,P=0.893); while the ALP contents increased in both of the 2 groups after the treatment(8.080+/-0.498 vs 9.090+/-0.452 μg/L,t=9.770,P=0.000; 8.096+/-0.500 vs 8.644+/-0.408 μg/L,t=6.495,P=0.000),and the ALP contents increased more significantly in the treatment group(1.010+/-0.618 vs 0.549+/-0.507 μg/L,t=3.463,P=0.001).Twelve patients got a good result,22 fair,and 2 poor in the treatment group; while 6 patients got a good result,21 fair,and 9 poor in the control group.The treatment group surpassed the control group in the total curative effect((-overR)treatment group=31.33,(-overR)control group=41.67,Z=-2.390,P=0.017).Conclusion:The JIEGUYAO pill can obviously increase the femoral BMD and ALP contents in the patients after hip hemiarthroplasty,and it has better preventative effects on periprosthetic osteoporosis compared with activated vitamin D.

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備注/Memo

備注/Memo:
2013-03-12收稿 2013-05-07修回
基金項目:山東省科技發(fā)展計劃項目(2010GFS10286)
更新日期/Last Update: 2013-09-30