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[1]郭會(huì)利,王軍輝,郭樹農(nóng),等.云克聯(lián)合筋骨痛消丸治療膝骨關(guān)節(jié)炎的臨床研究[J].中醫(yī)正骨,2013,25(06):24-28.
　GUO Hui-li*,WANG Jun-hui,GUO Shu-nong,et al.Clinical study on the curative effects and safety of Technetium-99 methylene diphosphonate injection combined with JINGU TONGXIAO pill in the treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(06):24-28.
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云克聯(lián)合筋骨痛消丸治療膝骨關(guān)節(jié)炎的臨床研究()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第25卷
期數(shù):
2013年06期
頁碼:
24-28
欄目:
臨床研究
出版日期:
2013-06-30

文章信息/Info

Title:
Clinical study on the curative effects and safety of Technetium-99 methylene diphosphonate injection combined with JINGU TONGXIAO pill in the treatment of knee osteoarthritis
作者:
郭會(huì)利; 王軍輝; 郭樹農(nóng); 劉玉珂; 張斌青; 張敏; 郭艷幸
河南省洛陽正骨醫(yī)院,河南 洛陽 471002
Author(s):
GUO Hui-li*; WANG Jun-hui; GUO Shu-nong; LIU Yu-ke; ZHANG Bin-qing; ZHANG Min; GUO Yan-xing.*
Luoyang Orthopedic-Traumatological Hospital,Luoyang 471002,Henan,China
關(guān)鍵詞:
骨關(guān)節(jié)炎; 膝 锝 亞甲基二膦酸鹽 筋骨痛消丸 單光子發(fā)射型計(jì)算機(jī)斷層成像 體層攝影術(shù); X線計(jì)算機(jī) 圖像融合 治療; 臨床研究性
Keywords:
Osteoarthritis; knee;  Technetium;  Methylenediphosphonate;  JINGU TONGXIAO PILL;  Single photon emission computerized tomography;  Tomography; X-ray computed;  Image fusion;  Therapies; investigational
摘要:
目的:觀察云克聯(lián)合筋骨痛消丸治療膝骨關(guān)節(jié)炎的臨床療效和安全性。方法:將納入研究的180例膝骨關(guān)節(jié)炎患者隨機(jī)分為云克治療組、中藥治療組和聯(lián)合治療組,每組60例。云克治療組患者靜脈滴注云克注射液,中藥治療組患者口服筋骨痛消丸,聯(lián)合治療組患者靜脈滴注云克注射液聯(lián)合口服筋骨痛消丸,均連續(xù)治療30 d。治療結(jié)束后根據(jù)自擬影像學(xué)評(píng)價(jià)標(biāo)準(zhǔn)、潘中允制定的膝骨關(guān)節(jié)炎癥狀體征評(píng)分標(biāo)準(zhǔn)和安全性評(píng)價(jià)標(biāo)準(zhǔn)評(píng)定3種治療方法的臨床療效和安全性。結(jié)果:①影像學(xué)評(píng)價(jià)結(jié)果。膝關(guān)節(jié)單光子發(fā)射型計(jì)算機(jī)斷層成像-計(jì)算機(jī)體層攝影融合圖像顯示,云克治療組和中藥治療組治療后放射性核素濃聚范圍和程度較治療前輕度縮小,聯(lián)合治療組治療后放射性核素濃聚范圍和程度較治療前均顯著縮小。云克治療組顯效45例,有效10例,無效5例; 中藥治療組顯效28例,有效20例,無效12例; 聯(lián)合治療組顯效52例,有效6例,無效2例。3組患者影像學(xué)評(píng)價(jià)結(jié)果比較,差異有統(tǒng)計(jì)學(xué)意義(χ2=24.098,P=0.000); 進(jìn)一步兩兩比較(校正α'=0.017),聯(lián)合治療組優(yōu)于中藥治療組(u=1 064.000,P=0.000); 云克治療組分別與中藥治療組和聯(lián)合治療組比較,差異均無統(tǒng)計(jì)學(xué)意義(u=1 180.000,P=0.021; u=1 585.000,P=0.100)。②癥狀體征評(píng)分結(jié)果。云克治療組顯效40例,有效15例,無效5例; 中藥治療組顯效29例,有效20例,無效11例; 聯(lián)合治療組顯效50例,有效7例,無效3例。3組患者治療后癥狀體征評(píng)分比較,差異有統(tǒng)計(jì)學(xué)意義(χ2=16.536,P=0.000); 進(jìn)一步兩兩比較(校正α'=0.017),聯(lián)合治療組優(yōu)于中藥治療組(u=1 145.000,P=0.011); 云克治療組分別與中藥治療組和聯(lián)合治療組比較,差異均無統(tǒng)計(jì)學(xué)意義(u=1 437.500,P=0.032; u=1 505.000,P=0.041)。③安全性評(píng)價(jià)結(jié)果。云克治療組Ⅰ級(jí)45例,Ⅱ級(jí)13例,Ⅲ級(jí)2例; 中藥治療組Ⅰ級(jí)51例,Ⅱ級(jí)8例,Ⅲ級(jí)1例; 聯(lián)合治療組Ⅰ級(jí)44例,Ⅱ級(jí)14例,Ⅲ級(jí)2例。3種治療方法安全性比較,差異無統(tǒng)計(jì)學(xué)意義(χ2=1.880,P=0.170)。結(jié)論:云克與筋骨痛消丸聯(lián)合應(yīng)用治療膝骨關(guān)節(jié)炎安全有效,值得臨床推廣應(yīng)用。
Abstract:
Objective:To observe the clinical curative effects and safety of Technetium-99(99Tc)methylene diphosphonate injection combined with JINGU TONGXIAO pill in the treatment of knee osteoarthritis(KOA).Methods:One hundred and eighty patients with KOA enrolled in the study were randomly divided into YunKe treatment group,Chinese medicine treatment group and combined treatment group,60 cases in each group.Patients in YunKe treatment group were administrated with intravenous drip of Technetium(99Tc)methylene diphosphonate injection,cases in Chinese medicine treatment group were administrated with oral application of JINGU TONGXIAO pill,while the rest in the combined treatment group were administrated with intravenous drip of Technetium(99Tc)methylene diphosphonate injection combined with oral application of JINGU TONGXIAO pill,and they were all consecutively treated for 30 days.After the treatment,the clinical curative effects and safety of the 3 kinds of treatment methods were respectively evaluated according to self-designed imaging evaluation criterion, scoring scale of signs and symptoms for KOA and safety assessment standards designed by Pan Zhong-yun.Results:The knee image of single photon emission computed tomography(SPECT)fusion with computed tomography,(CT)image showed that the range and degree of posttreatment radionuclide concentration for YunKe treatment group and Chinese medicine treatment group were all slightly decreased compared with those before the treatment,while they were decreased much more obviously in the combined treatment group.Forty-five patients achieved an excellent result,10 good and 5 poor in YunKe treatment group; 28 cases achieved an excellent result,20 good and 12 poor in Chinese medicine treatment group; and 52 cases achieved an excellent result,6 good and 2 poor in combined treatment group.There was statistical difference in imaging evaluation results among the 3 groups(χ2=24.098,P=0.000).Further multiple comparison(correction α'=0.017)indicated that combined treatment group surpassed Chinese medicine treatment group(u=1 064.000,P=0.000),while YunKe treatment group was not statistically different from both other two groups(YunKe treatment group vs Chinese medicine treatment group,u=1 180.000,P=0.021; YunKe treatment group vs combined treatment group,u=1 585.000,P=0.100).Forty patients achieved an excellent scoring of signs and symptoms,15 good and 5 poor in YunKe treatment group; 29 cases achieved an excellent scoring of signs and symptoms,20 good and 11 poor in Chinese medicine treatment group; and 50 cases achieved an excellent scoring of signs and symptoms,7 good and 3 poor in combined treatment group.There was statistical difference in the scoring of signs and symptoms for KOA among the 3 groups(χ2=16.536,P=0.000); Further multiple comparison(correction α'=0.017)indicated that combined treatment group surpassed Chinese medicine treatment group(u=1 145.000,P=0.011),while YunKe treatment group was not statistically different from both other two groups(YunKe treatment group vs Chinese medicine treatment group,u=1 437.500,P=0.032; YunKe treatment group vs combined treatment group,u=1 505.000,P=0.041).Forty five patients achieved gradeⅠsafety assessment results,13 gradeⅡand 2 gradeⅢin YunKe treatment group; 51 patients achieved gradeⅠsafety assessment results,8 gradeⅡand 1 grade Ⅲ in Chinese medicine treatment group; and 44 cases got gradeⅠ,14 gradeⅡand 2 grade Ⅲ in combined treatment group.There was no statistical difference in safety among the 3 groups(χ2=1.880,P=0.170).Conclusion:The therapy of Technetium-99(99Tc)methylene diphosphonate injection combined with JINGU TONGXIAO pill is effective and safe in the treatment of KOA,so it is worthy of popularizing in clinic.

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更新日期/Last Update: 1900-01-01