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[1]周正新,孫志濤,丁鍔.骨蝕寧膠囊對(duì)激素性股骨頭壞死患者凝血機(jī)制的影響[J].中醫(yī)正骨,2013,25(03):31-34.
　ZHOU Zheng-xin*,SUN Zhi-tao,DING E..Effect of GUSHINING capsule on blood coagulation mechanism for patients with steroid-induced necrosis of femoral head[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(03):31-34.
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骨蝕寧膠囊對(duì)激素性股骨頭壞死患者凝血機(jī)制的影響()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第25卷
期數(shù):
2013年03期
頁(yè)碼:
31-34
欄目:
股骨頭壞死
出版日期:
2013-03-20

文章信息/Info

Title:
Effect of GUSHINING capsule on blood coagulation mechanism for patients with steroid-induced necrosis of femoral head
作者:
周正新1; 孫志濤2; 丁鍔1
1.安徽省中醫(yī)院,安徽 合肥 230031;
2.廣州中醫(yī)藥大學(xué),廣東 廣州 510405
Author(s):
ZHOU Zheng-xin*; SUN Zhi-tao; DING E.
*Traditional Chinese Medical Hospital of Anhui Province,Hefei 230031,Anhui,China
關(guān)鍵詞:
股骨頭壞死 血液凝固 治療; 臨床研究性 骨蝕寧膠囊
Keywords:
Femur head necrosis;  Blood coagulation;  Therapies; investigational;  GUSHINING capsule
摘要:
目的:觀察骨蝕寧膠囊對(duì)激素性股骨頭壞死患者凝血機(jī)制的影響。方法:將納入研究的62例激素性股骨頭壞死患者隨機(jī)分為2組,骨蝕寧組32例,仙靈骨葆組30例。分別采用口服骨蝕寧膠囊和仙靈骨葆膠囊治療。分別于治療前和治療12個(gè)月后抽血測(cè)定并比較2組患者的血漿血栓素B2、6-酮-前列腺素F1α、P選擇素和血栓調(diào)節(jié)蛋白含量。結(jié)果:治療前骨蝕寧組和仙靈骨葆組患者的血漿血栓素B2、P選擇素、血栓調(diào)節(jié)蛋白和6-酮-前列腺素F1α含量比較,差異均無(wú)統(tǒng)計(jì)學(xué)意義[(27.95±7.08)ng·L-1,(28.99±4.43)ng·L-1,t=3.473,P=0.247;(11.76±2.11)μg·L-1,(11.43±1.26)μg·L-1,t=1.402,P=0.183;(7.15±1.74)μg·L-1,(7.84±0.91)μg·L-1,t=0.762,P=0.105;(52.35±13.61)ng·L-1,(44.27±7.54)ng·L-1,t=24.294,P=0.619]。治療后2組患者血漿血栓素B2、P選擇素和血栓調(diào)節(jié)蛋白的含量均下降[(16.19±4.88)ng·L-1,(20.90±4.09)ng·L-1;(6.40±1.81)μg·L-1,(7.65±1.01)μg·L-1;(3.55±1.28)μg·L-1,(6.21±1.62)μg·L-1],但骨蝕寧組下降更明顯[(11.76±2.20)ng·L-1,(8.09±0.34)ng·L-1,t=6.824,P=0.000;(5.36±0.30)μg·L-1,(3.78±0.25)μg·L-1,t=4.215,P=0.000;(3.60±0.46)μg·L-1,(1.63±0.71)μg·L-1,t=4.162,P=0.000]; 治療后骨蝕寧組和仙靈骨葆組患者的血漿6-酮-前列腺素F1α含量均上升[(161.04±19.46)ng·L-1,(119.80±14.21)ng·L-1],但骨蝕寧組上升更明顯[(108.69±5.85)ng·L-1,(75.53±6.67)ng·L-1; t=39.203,P=0.000]。結(jié)論:骨蝕寧膠囊能緩解激素引起的血管內(nèi)皮損害,抑制血小板聚集及預(yù)防血黏度增高,改善激素性股骨頭壞死患者股骨頭微循環(huán)和凝血功能,其作用優(yōu)于仙靈骨葆膠囊。
Abstract:
Objective:To observe the effect of GUSHINING capsule on blood coagulation mechanism for patients with steroid-induced necrosis of femoral head(SNFH).Methods:Sixty-two SNFH patients were included into the study and were randomly divided into 2 groups,32 patients were administrated with GUSHINING capsule(GUSHINING group),while the others were administrated with XIANLINGGUBAO capsule(XIANLINGGUBAO group).The contents of thromboxane B2(TXB2),6-keto-prostaglandin F1α(6-keto-PGF1α),P-selectin and thrombomodulin(TM)in blood plasma were detected and compared between the 2 groups before the treatment and 12 months after the treatment respectively.Results:There were no statistical differences in contents of TXB2,P-selectin,TM and 6-keto-PGF1α,in blood plasma between the 2 groups before the treatment[(27.95±7.08)ng·L-1,(28.99±4.43)ng·L-1,t=3.473,P=0.247;(11.76±2.11)μg·L-1,(11.43±1.26)μg·L-1,t=1.402,P=0.183;(7.15±1.74)μg·L-1,(7.84±0.91)μg·L-1,t=0.762,P=0.105;(52.35±13.61)ng·L-1,(44.27±7.54)ng·L-1,t=24.294,P=0.619].The contents of TXB2,P-selectin and TM in blood plasma of the 2 groups declined after the treatment[(16.19±4.88)ng·L-1,(20.90±4.09)ng·L-1;(6.40±1.81)μg·L-1,(7.65±1.01)μg·L-1;(3.55±1.28)μg·L-1,(6.21±1.62)μg·L-1],and there was a bigger decline in GUSHINING group compared to XIANLINGGUBAO group[(11.76±2.20)ng·L-1,(8.09±0.34)ng·L-1,t=6.824,P=0.000;(5.36±0.30)μg·L-1,(3.78±0.25)μg·L-1,t=4.215,P=0.000;(3.60±0.46)μg·L-1,(1.63±0.71)μg·L-1,t=4.162,P=0.000]; while the plasma 6-keto-PGF1α contents for the 2 groups increased after the treatment[(161.04±19.46)ng·L-1,(119.80±14.21)ng·L-1],and there was a bigger increase in GUSHINING group compared to XIANLINGGUBAO group[(108.69±5.85)ng·L-1,(75.53±6.67)ng·L-1; t=39.203,P=0.000].Conclusion:GUSHINING capsule can improve microcirculation and blood coagulation functions of femoral head for SNFH patients through relieving the steroid-induced injuries of vascular endothelium,prohibiting platelet aggregation and preventing the increase of blood viscosity.Furthermore,the effect of GUSHINING capsule is better than that of XIANLINGGUBAO capsule.

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備注/Memo

備注/Memo:
基金項(xiàng)目:安徽省衛(wèi)生廳課題(2009ZY15)
通訊作者:孫志濤 E-mail:[email protected]
更新日期/Last Update: 2013-03-20