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[1]鄭春松,葉蕻芝,蔡亮亮,等.基于計算機模擬探討六味地黃丸治療骨關節(jié)炎的多成分-多靶點作用[J].中醫(yī)正骨,2013,25(01):11-13.
　ZHENG Chun-song*,YE Hong-zhi,CAI Liang-liang,et al.Discussion on the multi-component and multi-target effect of LIUWEI DIHUANG pill in the treatment of osteoarthritis on the basis of computer simulation[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(01):11-13.
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基于計算機模擬探討六味地黃丸治療骨關節(jié)炎的多成分-多靶點作用()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第25卷
期數:
2013年01期
頁碼:
11-13
欄目:
基礎研究
出版日期:
2013-01-20

文章信息/Info

Title:
Discussion on the multi-component and multi-target effect of LIUWEI DIHUANG pill in the treatment of osteoarthritis on the basis of computer simulation
作者:
鄭春松; 葉蕻芝; 蔡亮亮; 陳加守; 魏磊生; 劉獻祥
福建中醫(yī)藥大學中西醫(yī)結合研究院,福建 福州 350108
Author(s):
ZHENG Chun-song*; YE Hong-zhi; CAI Liang-liang; CHEN Jia-shou; WEI Lei-sheng; LIU Xian-xiang.
*Academy of Integrated Traditional Chinese Medicine with Western Medicine of Fujian University of Traditional Chinese Medicine,Fuzhou 350122,Fujian,China
關鍵詞:
六味地黃湯 骨關節(jié)炎 計算機模擬 多成分-多靶點
Keywords:
LIUWEI DIHUANG Decoction;  Osteoarthritis;  Computer simulation;  Multi-component and multi-target
摘要:
目的:探討六味地黃丸治療骨關節(jié)炎的多成分-多靶點作用。方法:以六味地黃丸所含的183個化合物和與骨關節(jié)炎相關的13個靶點蛋白質為研究對象,利用描述符計算、主成分分析、分子對接等計算機模擬方法,分析六味地黃丸所含化合物的物理化學性質及其作用的靶點,并據此構建六味地黃丸多成分-多靶點作用網絡。結果:六味地黃丸所含化合物具有多樣的物理化學性質,這些化合物與治療骨關節(jié)炎藥物分子、類藥分子具有相似的化學空間。六味地黃丸多成分-多靶點網絡模型中每個化合物的平均靶點數為2.24,平均每個靶點與5個化合物相關聯。結論:六味地黃丸治療骨關節(jié)炎具有多成分、多靶點作用的特點,可能在治療骨關節(jié)炎方面具有良好的應用前景。
Abstract:
Objective:To explore the multi-component and multi-target effect of LIUWEI DIHUANG pill in the treatment of osteoarthritis.Methods:One hundred and eighty-three compounds contained in the LIUWEI DIHUANG pill and 13 target proteins related to osteoarthritis were taken as research objects to analyze the phy-chemical property and targets of compounds contained in the LIUWEI DIHUANG pill through such computer simulation methods as descriptor calculation,principal component analysis and molecular docking,and the networks of multi-component and multi-target effects of LIUWEI DIHUANG pill were established.Results:The components contained in LIUWEI DIHUANG pill had various phy-chemical property,and these components were similar to drug molecules or drug-like molecules for the treatment of osteoarthritis in the chemical space.The average number of targets was 2.24 in each compound contained in the multi-component and multi-target network model of LIUWEI DIHUANG pill,and every target was related to 5 compounds on average.Conclusion:LIUWEI DIHUANG pill has multi-component and multi-target features in the treatment of osteoarthritis,and it will probably have good application prospect in osteoarthritis treatment.

參考文獻/References:

[1] 張保國,劉慶芳.六味地黃丸(湯)藥效研究新進展[J].中成藥,2007,29(7):1052-1057.
[2] 肖經難,謝丹,祁開澤.六味地黃丸對兔骨關節(jié)炎軟骨細胞凋亡的影響[J].湖南中醫(yī)學院學報,2003,23(5):11-13.
[3] 楚世峰,張均田.人參皂苷Rg1的多靶點作用和機制分析[J].醫(yī)學研究雜志,2010,39(5):11-15.
[4] 鄭春松,徐筱杰,劉獻祥,等.精制透骨消痛顆粒防治骨性關節(jié)炎的計算機藥理學[J].物理化學學報,2010,26(3):775-783.
[5] 鄭春松,葉蕻芝,李西海,等.分子對接法對補腎壯筋湯治療骨性關節(jié)炎有效成分群的研究[J].中醫(yī)正骨,2012,24(1):8-10.
[6] 周家駒,謝桂榮,嚴新建.中藥原植物化學成分手冊[M].北京:化學工業(yè)出版社,2004:1165-1211.
[7] Qiao X,Hou T,Zhang W,et al.A 3D structure database of components from Chinese traditional medicinal herbs[J].J Chem Inf Comput Sci,2002,42(3):481-489.
[8] Wishart DS,Knox C,Guo AC,et al.DrugBank:a knowledgebase for drugs,drug actions and drug targets[J].Nucleic Acids Res,2008,36(Database issue):D901-D906.
[9] 鄭春松,徐筱杰,葉蕻芝,等.青風藤治療骨性關節(jié)炎藥效物質基礎多靶導向作用的計算機模擬研究[J].中國中西醫(yī)結合雜志,2012,32(3):375-379.
[10] 劉永剛,鮑雋君,邢自寶,等.骨性關節(jié)炎與細胞因子相關性研究進展[J].骨科,2010,1(2):105-107.
[11] Dobson CM.Chemical space and biology[J].Nature,2004,432(7019):824-828.
[12] Gu J,Zhang H,Chen L,et al.Drug-target network and polypharmacology studies of a Traditional Chinese Medicine for typeⅡ diabetes mellitus[J].Comput Biol Chem,2011,35(5):293-297.
[13] Tang Y,Carbonetta D,Shetty S.Development of an integrated network visualisation and graph analysis tool for biological networks[J].Int J Comput Biol Drug Des,2012,5(2):152-163.
[14] 王嬙,梅煥平.骨性關節(jié)炎軟骨修復與基因治療[J].中華臨床免疫和變態(tài)反應雜志,2008,2(1):41-44.
[15] 蔣能英.試論六味地黃丸[J].中國現代醫(yī)生,2008,46(7):92-93.
[16] 李西海,陳文列,劉獻祥.補腎柔肝法防治骨性關節(jié)炎作用機制探討[J].福建中醫(yī)藥大學學報,2011,21(2):66-69.
[17] 杜以寬,馬民,唐勇.中醫(yī)對骨性關節(jié)炎病因病機的認識[J].浙江中醫(yī)藥大學學報,2009,33(2):155-156.
[18] 李旭東,黃欽,徐筱杰.中藥方劑血府逐瘀湯中分子在靶標-配體空間的分布[J].物理化學學報,2008,24(4):547-551.
[19] 徐筱杰.中藥復方的計算機模擬研究[J].化學進展,1999,19(2):202-203.

備注/Memo

備注/Memo:
基金項目:國家自然科學基金(81202713),陳可冀中西醫(yī)結合發(fā)展基金(CKJ2010032),福建省自然科學基金(2010J01196)
通訊作者:劉獻祥 E-mail:[email protected]
更新日期/Last Update: 2013-01-20