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[1]單海民,程春生,李剛,等.Ⅰ型牛膠原蛋白生物膜預(yù)防屈指肌腱損傷術(shù)后粘連的臨床研究[J].中醫(yī)正骨,2012,24(12):27-29.
　SHAN Hai-min*,CHENG Chun-sheng,LI Gang,et al.Clinical study on the role of biomembrane made of bovine type-Ⅰcollagen protein in the prevention of postoperative finger flexor tendon adhesion formation[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2012,24(12):27-29.
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Ⅰ型牛膠原蛋白生物膜預(yù)防屈指肌腱損傷術(shù)后粘連的臨床研究()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第24卷
期數(shù):
2012年12期
頁(yè)碼:
27-29
欄目:
臨床研究
出版日期:
2012-12-20

文章信息/Info

Title:
Clinical study on the role of biomembrane made of bovine type-Ⅰcollagen protein in the prevention of postoperative finger flexor tendon adhesion formation
作者:
單海民1; 程春生1; 李剛2; 趙治偉1; 程真真1; 石寧寧1; 田濤濤2
1.河南省洛陽(yáng)正骨醫(yī)院,河南 洛陽(yáng) 471002;
2.湖南中醫(yī)藥大學(xué),湖南 長(zhǎng)沙 410000
Author(s):
SHAN Hai-min*; CHENG Chun-sheng; LI Gang; ZHAO Zhi-wei; CHENG Zhen-zhen; SHI Ning-ning; TIAN Tao-tao
*Luoyang Orthopedic-Traumatological Hospital,Luoyang 471002,Henan,China
關(guān)鍵詞:
手損傷 膠原Ⅰ型 肌腱粘連 治療; 臨床研究性
Keywords:
Hand injuries;  Collagen type Ⅰ;  Adhesion of tendon;  Therapies; investigational
摘要:
目的:觀察Ⅰ型牛膠原蛋白生物膜預(yù)防屈指肌腱損傷術(shù)后粘連的臨床療效和安全性。方法:按要求選取72例手部Ⅱ區(qū)新鮮屈指肌腱損傷患者,男43例,女29例。年齡16～55歲,中位數(shù)37.5歲。實(shí)驗(yàn)方案通過(guò)醫(yī)院倫理委員會(huì)的論證。采用隨機(jī)數(shù)字表將72例患者隨機(jī)分為2組,每組36例。2組均采用改良Kessler肌腱縫合法修復(fù)肌腱,治療組用Ⅰ型牛膠原蛋白生物膜包繞吻合的肌腱斷端,對(duì)照組在損傷局部不使用任何藥物及特殊處理。觀察記錄患者治療期間及治療后血尿常規(guī)、生化指標(biāo)及心電圖有無(wú)異常,及有無(wú)肌腱再斷裂等不良事件發(fā)生。并于術(shù)后第8周采用中華醫(yī)學(xué)會(huì)手外科學(xué)會(huì)手部肌腱修復(fù)后評(píng)定標(biāo)準(zhǔn)評(píng)定2組患者的手部肌腱總主動(dòng)活動(dòng)度。結(jié)果:①安全性。2組患者術(shù)后切口均一期愈合,無(wú)感染及肌腱再次斷裂; 血尿常規(guī)、生化指標(biāo)及心電圖未見(jiàn)異常。②手部肌腱總主動(dòng)活動(dòng)度。治療組優(yōu)19例,良11例,可5例,差1例; 對(duì)照組優(yōu)8例,良10例,可13例,差5例。治療組手部肌腱總主動(dòng)活動(dòng)度優(yōu)于對(duì)照組(Z=-3.229,P=0.001)。結(jié)論:Ⅰ型牛膠原蛋白生物膜能安全、有效地預(yù)防屈指肌腱損傷術(shù)后粘連。
Abstract:
Objective:To observe the clinical curative effect and safety of biomembrane made of bovine type-Ⅰcollagen protein in the prevention of postoperative finger flexor tendon adhesion formation.Methods:Seventy-two patients with fresh flexor tendon injuries in zoneⅡof hands were selected according to the requirements,male 43 cases,while female 29 cases,ranging in age from 16 to 55 years with a median of 37.5 years.Research Ethics Committee approval was obtained.The 72 patients were randomly divided into 2 groups according to random digits table,36 cases in each group.The injured tendons of patients in the 2 groups were all repaired through modified Kessler tendon suture.Cases in the treatment group were administrated with biomembrane made of bovine type-Ⅰcollagen protein surrounded anastomotic broken ends of tendon,while the others in the control group were administrated without any drug or special treatment in the local injuries.The results of routine blood test,routine urine test,biochemical indicator test and electrocardiogram were observed and recorded during and after the treatment,and the occurrence of tendon re-rupture and other adverse events were also observed and recorded.The total active range of motion of hand tendons in the 2 groups were evaluated according to the repaired hand tendon evaluation standards set up by hand surgery branch of Chinese Medical Association at the 8th week after the operation.Results:①Safety.All of the patients in the 2 groups got primary healing in the operative incisions,without infection and tendon re-rupture; and no abnormal results of routine blood test,routine urine test,biochemical indicator test and electrocardiogram were found in the 2 groups.②Total active range of motion of hand tendons.Nineteen patients got excellent outcomes,11 good,5 fair and 1 poor in the treatment group; while 8 patients got excellent outcomes,10 good,13 fair and 5 poor in the control group.The total active range of motion of hand tendon in the treatment group was better than that in the control group(Z=-3.229,P=0.001).Conclusion:Biomembrane made of bovine type-Ⅰcollagen protein can safely and effectively prevent postoperative finger flexor tendon adhesion formation.

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備注/Memo

備注/Memo:
基金項(xiàng)目:河南省省屬科研單位社會(huì)公益項(xiàng)目專(zhuān)項(xiàng)資金
更新日期/Last Update: 2012-12-20