84年鼠女哪年财运最旺,857comvvv色九欧美激情|85PO_87国产精品欲av国产av资源

[1]張萬義,張永紅,王笑青.雙醋瑞因膠囊聯(lián)合柳氮磺胺吡啶腸溶片與右旋布洛芬膠囊治療強(qiáng)直性脊柱炎[J].中醫(yī)正骨,2012,24(06):26-28.
　ZHANG Wan-yi*,ZHANG Yong-hong,WANG Xiao-qing.*.Study on the curative effects of diacerein capsules combined with sulfasalazine enteric-coated tablets and dextral ibuprofen capsules in the treatment of ankylosing spondylitis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2012,24(06):26-28.
點(diǎn)擊復(fù)制

雙醋瑞因膠囊聯(lián)合柳氮磺胺吡啶腸溶片與右旋布洛芬膠囊治療強(qiáng)直性脊柱炎()
分享到：

《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第24卷
期數(shù):
2012年06期
頁碼:
26-28
欄目:
臨床研究
出版日期:
2012-06-30

文章信息/Info

Title:
Study on the curative effects of diacerein capsules combined with sulfasalazine enteric-coated tablets and dextral ibuprofen capsules in the treatment of ankylosing spondylitis
作者:
張萬義1; 張永紅2; 王笑青2
1.河南中醫(yī)學(xué)院2009級(jí)碩士研究生，河南鄭州450008；
2.河南省洛陽正骨醫(yī)院，河南洛陽471002
Author(s):
ZHANG Wan-yi*; ZHANG Yong-hong; WANG Xiao-qing.*
2009 Master candidate of Henan University of Traditional Chinese Medicine,Zhengzhou 450008,Henan,China
關(guān)鍵詞:
脊柱炎; 強(qiáng)直性　雙醋瑞因　柳氮磺胺吡啶　布洛芬
Keywords:
Spondylitis; ankylosing; Diacerein; Sulfasalazine; Ibuprofen
摘要:
目的：觀察雙醋瑞因膠囊聯(lián)合柳氮磺胺吡啶腸溶片與右旋布洛芬膠囊治療強(qiáng)直性脊柱炎的臨床療效及安全性。方法：將60 例強(qiáng)直性脊柱炎患者隨機(jī)分為2組，治療組（40例）采用雙醋瑞因膠囊聯(lián)合柳氮磺胺吡啶腸溶片與右旋布洛芬膠囊治療，對(duì)照組 （20例）采用柳氮磺胺吡啶腸溶片與右旋布洛芬膠囊治療。3個(gè)療程后比較2組患者血沉下降幅度、C反應(yīng)蛋白下降幅度、關(guān)節(jié)痛 和腰背部疼痛評(píng)分變化情況及總體療效。結(jié)果：①治療組血沉下降幅度大于對(duì)照組（t=2.509，P=0.017）；治療組與對(duì)照 組C反應(yīng)蛋白下降幅度比較，差異無統(tǒng)計(jì)學(xué)意義（t=-0.078，P=0.938）；治療組關(guān)節(jié)痛和腰背部疼痛評(píng)分下降幅度大于對(duì) 照組（t=-2.686，P=0.010）。②治療組臨床療效優(yōu)于對(duì)照組（Z=-2.106，P=0.035）。③治療組不良反應(yīng)主要表現(xiàn)為 輕度腹瀉3例，上腹部疼痛2例，白細(xì)胞數(shù)升高2例，白細(xì)胞數(shù)降低1例，惡心、嘔吐1例；對(duì)照組不良反應(yīng)主要表現(xiàn)為腹脹2例， 惡心1例，肝功能輕度異常1例。2組患者均未出現(xiàn)尿常規(guī)及腎功能明顯異常。結(jié)論：采用雙醋瑞因膠囊聯(lián)合柳氮磺胺吡啶腸溶片 與右旋布洛芬膠囊治療AS，能夠降低急性期反應(yīng)物指標(biāo)，緩解關(guān)節(jié)及腰背部疼痛，療效確切，且不良反應(yīng)輕微，值得臨床推廣 引用。
Abstract:
Objective:To observe the clinical curative effects and safety of diacerein capsules combined with sulfasalazine enteric-coated tablets and dextral ibuprofen capsules in the treatment of ankylosing spondylitis(AS).Methods:Sixty AS patients were randomly divided into 2 groups.Forty cases in treatment group were administrated with diacerein capsules combined with sulfasalazine enteric-coated tablets and dextral ibuprofen capsules,while the others in the control group were administrated with sulfasalazine enteric-coated tablets and dextral ibuprofen capsules.The following indexes as erythrocyte sedimentation rate(ESR),c-reactive protein(CRP),visual analogue scores(VAS) of arthralgia and lumbus-back pain and the overall curative effects of the patients were compared between the 2 groups after three courses of treatment.Results:①The decreasing degree of ESR in treatment group was superior to that in control group(t=2.509,P=0.017).There was no statistical difference between treatment group and control group in the decreasing degree of CRP(t=-0.078,P =0.938).The decreasing degree of VAS of arthralgia and lumbar-back pain in treatment group was superior to that in control group(t=-2.686,P=0.010).②The clinical curative effect of treatment group was better than that of control group(Z=-2.106,P=0.035).③The adverse reactions in treatment group were mainly reflected as 3 cases with mild diarrhea,2 cases with upper abdominal pain,2 cases with increased number of white blood cells,1 case with decreased number of white blood cells and 1 case with nausea and vomiting.And the adverse reactions in control group were mainly reflected as 2 cases with abdominal distension,1 case with nausea and 1 case with mild abnormalities in hepatic function.No obvious abnormities of uric convention and renal function were found in both groups.Conclusion:The therapy of diacerein capsules combined with sulfasalazine enteric-coated tablets and dextral ibuprofen capsules can reduce acute phase reactant index and relieve the pain in joint and lumbus-back when it is used in the treatment of AS,furthermore,it has certain curative effects with mild adverse reactions,and it is worthy of popularizing in clinic.

參考文獻(xiàn)/References:

[1]吳文,黃國志,陳銀海.強(qiáng)直性脊柱炎誤診分析及康復(fù)措施[J].中國康復(fù)醫(yī)學(xué)雜志,2002,17(5):299-300.
[2]中華醫(yī)學(xué)會(huì).臨床診療指南:風(fēng)濕病分冊(cè)[M].北京:人民衛(wèi)生出版社,2005:23-24.
[3]國家中醫(yī)藥管理局.中醫(yī)病證診斷療效標(biāo)準(zhǔn)[S].南京:南京大學(xué)出版社,1994:29.
[4]Ivashkiv LB.Cytokine expreesion and cell activation in inflammatory arthritis[J].Adv Immunol,1996,(63):337- 376.
[5]Wong BR,Josien R,Lee SY,et al.The TRAF family of signal transducers mediaters NF-kappaB activation by the TRANCE receptor[J].J Biol Chem,1998,273(43):28355-28359.
[6]葉俏,杜瑛媛,顧旭東,等.強(qiáng)直性脊柱炎患者血清白介素1β、2、6及腫瘤壞死因子-α測(cè)定的意義[J].中華物理醫(yī)學(xué)與康復(fù)雜 志,2008, 30(3):162-164.
[7]林琳,陳文貴,扈鳳平.湖南籍漢族強(qiáng)直性脊柱炎患者IL-1RN基因多態(tài)性分析[J].湖南師范大學(xué)學(xué)報(bào):醫(yī)學(xué)版,2006,3(1):39- 41.
[8]Domagala F,Martin G,Bogdanowicz P,et al.Inhitibion of interleukin-1beta-induced activation of MEK/ERK pathway and DNA binding of NF-kappaB and AP-1:potential mechanism for Diacerein effects in osteoarthritis [J].Biorheology,2006,43(3-4):577-87.
[9]Dougados M,Nguyen M,Berdah L,et al.Evaluation of the structure-modifying effects of diacerein in hip osteoarthritis:ECHODIAH,a three-year,placebo-contralled trial.Evaluation of the chondromodulating effect of diacerein in OA of the Hip.[J].Arthritis Rheum,2001,44(11):2539-2547.

相似文獻(xiàn)/References:

[1]戴霞華,李寅潔.指導(dǎo)性功能鍛煉在兒童強(qiáng)直性脊柱炎護(hù)理中的應(yīng)用[J].中醫(yī)正骨,2015,27(10):78.
[2]張夢(mèng)雨,鮑鐵周,田江波.督脈隔姜灸聯(lián)合柳氮磺吡啶腸溶片口服及 功能鍛煉治療強(qiáng)直性脊柱炎[J].中醫(yī)正骨,2015,27(09):44.
[3]閻曉霞,任之強(qiáng),仝允輝,等.布魯氏菌性脊柱炎3例[J].中醫(yī)正骨,2015,27(06):64.
[4]黃建武,黃建華,黃影.腫瘤壞死因子-α在強(qiáng)直性脊柱炎活動(dòng)期患者中的表達(dá)[J].中醫(yī)正骨,2013,25(11):22.
[5]張董喆,孔超,張建福.針刺夾脊穴結(jié)合督灸治療強(qiáng)直性脊柱炎[J].中醫(yī)正骨,2014,26(07):58.
[6]吳建國.強(qiáng)直性脊柱炎并發(fā)脊柱骨折的影像學(xué)表現(xiàn)[J].中醫(yī)正骨,2013,25(06):31.
[7]謝國華,薛峰,楊建平,等.強(qiáng)直性脊柱炎脊柱應(yīng)力性骨折的診斷[J].中醫(yī)正骨,2012,24(12):72.
[8]黃建華,黃建武,陳金春,等.早期強(qiáng)直性脊柱炎血管內(nèi)皮生長因子、C反應(yīng)蛋白 表達(dá)水平的臨床研究[J].中醫(yī)正骨,2012,24(02):9.
　HUANG Jian-hua*,HUANG Jian-wu,CHEN Jin-chun,et al.Clinical research on the expression of VEGF、CRP in early ankylosing spondylitis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2012,24(06):9.
[9]王笑青,張永紅,王玉麗,等.常規(guī)藥物口服配合中藥離子導(dǎo)入治療強(qiáng)直性脊柱炎肌腱附著點(diǎn)炎[J].中醫(yī)正骨,2011,23(10):18.
　WANG Xiao-qing*,ZHANG Yong-hong,WANG Yu-li,et al.A study on the curative effects of oral conventional drugs combined with traditional Chinese medicine iontophoresis on ankylosing spondylitis tendon enthesitis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2011,23(06):18.
[10]劉紅軍.單節(jié)段楔形截骨結(jié)合椎弓根A-F系統(tǒng)內(nèi)固定 治療強(qiáng)直性脊柱炎脊柱后凸畸形[J].中醫(yī)正骨,2011,23(09):65.

備注/Memo

備注/Memo:
2011-10-26收稿2012-02-18修回
更新日期/Last Update: 2012-06-30