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[1]陳俊杰,李晴晴,夏瑢.脂代謝及血清內(nèi)脂素水平與絕經(jīng)后骨質(zhì)疏松癥的 相關(guān)性研究[J].中醫(yī)正骨,2012,24(04):16-18.
　CHEN Jun-jie*,LI Qing-qing,XIA Rong.*.Study on the correlations between the levels of lipid metabolism and serum visfatin and postmenopausal osteoporosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2012,24(04):16-18.
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脂代謝及血清內(nèi)脂素水平與絕經(jīng)后骨質(zhì)疏松癥的 相關(guān)性研究()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第24卷
期數(shù):
2012年04期
頁(yè)碼:
16-18
欄目:
臨床研究
出版日期:
2012-04-30

文章信息/Info

Title:
Study on the correlations between the levels of lipid metabolism and serum visfatin and postmenopausal osteoporosis
作者:
陳俊杰1; 李晴晴1; 夏瑢2
1.浙江省中醫(yī)院,浙江 杭州 310006;
2.浙江中醫(yī)藥大學(xué),浙江 杭州 310053
Author(s):
CHEN Jun-jie*; LI Qing-qing; XIA Rong.*
Hospital of Chinese medicine of Zhejiang Province,Hangzhou 310006,Zhejiang,China
關(guān)鍵詞:
骨質(zhì)疏松; 絕經(jīng)后 脂代謝障礙 煙酰胺磷酸核糖基轉(zhuǎn)移酶 直線相關(guān)分析
Keywords:
Osteoporosis; postmenopausal;  Lipid metabolism disorders;  Nicotinamide phosphoribosylstranferase;  Linear correlation
摘要:
目的:探討脂代謝及血清內(nèi)脂素水平與絕經(jīng)后骨質(zhì)疏松癥的相關(guān)性。方法:依據(jù)1994年世界衛(wèi)生組織骨質(zhì)疏松癥診斷標(biāo)準(zhǔn),選取2010年3月至2011年5月在浙江省中醫(yī)院骨科就診的絕經(jīng)1年以上的女性骨量減少與骨質(zhì)疏松癥患者各30例作為研究對(duì)象; 檢測(cè)患者血清中血脂、內(nèi)脂素及骨代謝指標(biāo)的水平,分析對(duì)比骨質(zhì)疏松癥患者與骨量減少患者血脂及內(nèi)脂素水平的差異; 并分別對(duì)血脂、內(nèi)脂素水平與骨密度、骨代謝指標(biāo)間的相關(guān)性作直線相關(guān)分析。結(jié)果:骨質(zhì)疏松組患者血清中總膽固醇含量和內(nèi)脂素水平均高于骨量減少組(t=-2.481,P=0.016; t=-2.850,P=0.006); 患者血清中總膽固醇和內(nèi)脂素水平均與骨密度呈負(fù)相關(guān)(r=-0.524,P=0.000; r=-0.523,P=0.000); 與骨吸收指標(biāo)抗酒石酸酸性磷酸酶呈正相關(guān)(r=0.426,P=0.001; r=0.674,P=0.000); 與骨形成指標(biāo)骨型堿性磷酸酶無(wú)相關(guān)性(r=-0.208,P=0.110; r=-0.240,P=0.065)。結(jié)論:脂代謝障礙,血清總膽固醇水平升高及內(nèi)脂素異常表達(dá)可能具有影響骨代謝、加快骨吸收的作用,并由此影響絕經(jīng)后骨質(zhì)疏松癥的發(fā)病,但其具體機(jī)制仍需進(jìn)一步研究。
Abstract:
Objective:To explore the correlations between the levels of lipid metabolism and serum visfatin and postmenopausal osteoporosis(PMOP).Methods:According to the diagnostic criteria of osteoporosis formulated by world health organization in 1994,30 cases with osteopenia and 30 cases with osteoporosis were selected from the female patients with menopausal period more than 1 year and treated in orthopaedic department of Hospital of Chinese medicine of Zhejiang Province from March 2010 to May 2011.The levels of lipid,visfatin and index of bone metabolism in blood serum of patients were measured.The differences in levels of lipid and visfatin were analyzed and compared between osteoporosis patients and osteopenia patients.Linear correlation analysis was made on the relationships among lipid,visfatin level,bone mineral density(BMD)and bone metabolism index respectively.Results:Cholesterol total(CHOL)contents and visfatin levels in blood serum of osteoporosis patients were all higher than those of osteopenia patients(t=-2.481,P=0.016; t=-2.850,P=0.006).Both serum CHOL level and serum visfatin level were correlated negatively with BMD(r=-0.524,P=0.000; r=-0.523,P=0.000)and were correlated positively with the level of tartrate-resistant acid phosphatase(r=0.426,P=0.001; r=0.674,P=0.000)and had no correlations with the level of bone alkaline phosphatase(r=-0.208,P=0.110; r=-0.240,P=0.065).Conclusion:As the result of lipid metabolism disorders,elevated levels of serum CHOL and abnormal expression of visfatin may have effects on PMOP attack through affecting bone metabolism and speeding up bone absorption,however,the concrete mechanism shoule be further studied.

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備注/Memo

備注/Memo:
2011-09-04收稿 2012-02-03修回
基金項(xiàng)目:浙江省中醫(yī)管理局科研專項(xiàng)課題(20050832)
通訊作者:夏瑢 E-mail:[email protected]
更新日期/Last Update: 2012-04-30