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[1]黃建華,黃建武,陳金春,等.早期強(qiáng)直性脊柱炎血管內(nèi)皮生長(zhǎng)因子、C反應(yīng)蛋白 表達(dá)水平的臨床研究[J].中醫(yī)正骨,2012,24(02):9-10.
　HUANG Jian-hua*,HUANG Jian-wu,CHEN Jin-chun,et al.Clinical research on the expression of VEGF、CRP in early ankylosing spondylitis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2012,24(02):9-10.
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早期強(qiáng)直性脊柱炎血管內(nèi)皮生長(zhǎng)因子、C反應(yīng)蛋白 表達(dá)水平的臨床研究()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第24卷
期數(shù):
2012年02期
頁(yè)碼:
9-10
欄目:
基礎(chǔ)研究
出版日期:
2012-02-25

文章信息/Info

Title:
Clinical research on the expression of VEGF、CRP in early ankylosing spondylitis
作者:
黃建華; 黃建武; 陳金春; 李強(qiáng)
溫州醫(yī)學(xué)院附屬第三醫(yī)院,浙江 瑞安 325200
Author(s):
HUANG Jian- hua*; HUANG Jian-wu; CHEN Jin-chun; LI Qiang.*
The affiliated No.3 Hospital of Wenzhou Medical College,Ruian 325200,Zhejiang,China
關(guān)鍵詞:
脊柱炎; 強(qiáng)直性 血管內(nèi)皮生長(zhǎng)因子類 C反應(yīng)蛋白 生物醫(yī)學(xué)研究
Keywords:
Early ankylosing spondylitis;  VEGF;  CRP;  Clinical Research
摘要:
目的:探討血清血管內(nèi)皮生長(zhǎng)因子與C反應(yīng)蛋白在早期強(qiáng)直性脊柱炎患者發(fā)病中的作用及表達(dá)水平。方法:采用免疫學(xué)方法 ,檢測(cè)53例早期強(qiáng)直性脊柱炎患者和39名健康對(duì)照者血清中血管內(nèi)皮生長(zhǎng)因子及C反應(yīng)蛋白水平,進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果:早期強(qiáng) 直性脊柱炎患者組中血清血管內(nèi)皮生長(zhǎng)因子、C反應(yīng)蛋白水平均顯著高于健康對(duì)照組(P<0.05),表明血管內(nèi)皮生長(zhǎng)因子、C反 應(yīng)蛋白是早期強(qiáng)直性脊柱炎患者發(fā)病過(guò)程中的重要炎癥指標(biāo)。結(jié)論:血管內(nèi)皮生長(zhǎng)因子是與強(qiáng)直性脊柱炎發(fā)病相關(guān)的細(xì)胞因子, 直接或間接參與早期強(qiáng)直性脊柱炎炎癥的發(fā)生、血管增生及關(guān)節(jié)軟骨破壞等病理過(guò)程,聯(lián)合C反應(yīng)蛋白檢測(cè)可能更好的反映了參 與疾病活動(dòng)性的指標(biāo),可以有效的應(yīng)用于強(qiáng)直性脊柱炎的早期活動(dòng)期實(shí)驗(yàn)室指標(biāo)輔助診斷的檢測(cè)方法。
Abstract:
Objective:To explore the expression and effect of VEGF,CRP in early ankylosing spondylitis(AS) patients.Methods:VEGF and CRP were measured and analized in 53 patients with early AS and another 39 cases in healthy control group.Results:The serum VEGF、CRP level in the AS patients was significantly higher than that in the control group(P<0.05),it show that the level of VEGF and CRP was important indicator of inflammation in the early AS patients.Conclusion:VEGF is a cytokine associated with AS disease,directly or indirectly involved in the early AS inflammation and vascular proliferation and pathological processes of articular cartilage destruction,it may better reflect the disease activity together with CRP testing,and it can be effectively used as laboratory markers for early diagnosis of active detection.

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備注/Memo

備注/Memo:
2011-06-30收稿 2011-09-21修回
更新日期/Last Update: 2012-02-25