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[1]王偉東,陳如平,肖魯偉,等.雷公藤甲素對類風濕關(guān)節(jié)炎滑膜新生血管中 血管內(nèi)皮生長因子、白細胞介素-6抑制機理的探討[J].中醫(yī)正骨,2012,24(02):3-5.
　WANG Wei-dong*,CHEN Ru-ping,XIAO Lu-wei,et al.Inhibitory mechanism of Triptolide on the expression of VEGF,IL-6 in rheumatoid arthritis synovial membrane newborn blood vessel[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2012,24(02):3-5.
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雷公藤甲素對類風濕關(guān)節(jié)炎滑膜新生血管中 血管內(nèi)皮生長因子、白細胞介素-6抑制機理的探討()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第24卷
期數(shù):
2012年02期
頁碼:
3-5
欄目:
基礎(chǔ)研究
出版日期:
2012-02-25

文章信息/Info

Title:
Inhibitory mechanism of Triptolide on the expression of VEGF,IL-6 in rheumatoid arthritis synovial membrane newborn blood vessel
作者:
王偉東; 陳如平; 肖魯偉; 王昌興; 成鋒
浙江中醫(yī)藥大學附屬第二醫(yī)院,浙江 杭州 310005
Author(s):
WANG Wei-dong*; CHEN Ru-ping; XIAO Lu-wei; WANG Chang-xing; CHENG Feng.*
The affiliated No.2 hospital of Zhejiang TCM university,Hangzhou 310005,Zhejiang,China
關(guān)鍵詞:
雷公藤內(nèi)脂 關(guān)節(jié)炎; 類風濕 血管內(nèi)皮生長因子類 白細胞介類類 動物實驗
Keywords:
Triptolide;  Rheumatoid arthritis;  Angiogenesis;  Immunohistochemistry
摘要:
目的:了解雷公藤甲素對類風濕關(guān)節(jié)炎中血管內(nèi)皮生長因子、白細胞介素-6的影響,探討雷公藤對類風濕關(guān)節(jié)炎患者滑膜新生血管的抑制機理。方法:應用免疫組化技術(shù)檢測血管內(nèi)皮生長因子、白細胞介素-6在AA大鼠踝關(guān)節(jié)滑膜組織中的表達,并觀察了雷公藤對其的影響。 結(jié)果:雷公藤組可見少量的血管內(nèi)皮生長因子陽性細胞,與對照組比較差異有統(tǒng)計學意義(P<0.01)。大鼠滑膜關(guān)節(jié)腔滑液中白細胞介素-6水平檢測中,實驗顯示對照組滑膜組織中白細胞介素-6的水平明顯高于空白組和雷公藤組(P<0.01)。結(jié)論:雷公藤甲素能降低滑膜組織血管內(nèi)皮生長因子、白細胞介素-6的表達水平,抑制血管生成。
Abstract:
Objective:To investigate the effect and inhibitory mechanisms of Triptolide on VEGF,IL-6 in rheumatoid arthritis synovial membrane newborn blood vessel.Methods:Use immunohistochemical techniques to detect expression of VEGF,IL-6 in the AA rats in the organization of the synovial organization,and to observe the effects of tripterygium wilfordii on the expression of VEGF,IL-6.Results:VEGF positive cells were visible in the tripterygium wilfordii group,there was significant difference(P<0.01)compared with the experimental group.In the rat synovial articular cavity synovial fluid IL-6 level detection,IL-6 level in the experimental group synovial organization is significantly higher than the level of blank and tripterygium wilfordii group (P<0.01).Conclusion:Triptolide can reduce the expression of VEGF and IL-6 in synovial organizations and inhibit angiogenesis.

參考文獻/References:

[1] Roccaro AM,Russo F,Cirulli T,et al.Antiangiogenesis for rheumatoid arthritis[J].Curr Drugs Targets Inflammation Allergy,2005,4(1):27-30.
[2] 水光興,萬毅剛,蔣春明,等.雷公藤及其活性成分藥效學和藥理學研究的若干進展[J].中國中醫(yī)藥雜志,2010,35(4):515- 520.
[3] 黃慧琴.雷公藤內(nèi)酯醇對大鼠佐劑性關(guān)節(jié)炎的影響[J].福建醫(yī)藥雜志,2008,30(1):87-89.
[4] Saidenberg KN,Cohen SM,Bessis N,et al.Role for osteoprotegerin in rheumatoid inflammation[J].Joint Bone Spine,2004,71(1):9-13.
[5] Fava RA,Olsen NJ,SPeneer-Green G,et al.Vascula Permeability factor/endothelial growth factor(VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue[J].J ExP Med 1994,180 (1):341-346.
[6] Kang HY,Shim D,Kang SS,et al.Protein kinase B inhibit endostatin-induced apoptosis in HUVECs[J].J Biochem MolBiol,2006,39(7):97-104.
[7] Campo GM,Avenoso A,Campo S,et al.Differential effect of molecular mass hyaluronan on lipopolysacch a-ride- induced damage in chondrocytes[J].Innate Immun,2010,16(1):48-63.
[8] Casanova JL,Abel L.Primary immunodefieieneies:a field in its infancy[J].Science,2007,317(5838):617-619.

備注/Memo

備注/Memo:
2011-01-09收稿 2011-10-23修回
基金項目:2008年浙江省中醫(yī)藥青年課題資助項目(2008YA010)
更新日期/Last Update: 2012-02-25