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[1]陳海東,王培民,范競(jìng).膝骨性關(guān)節(jié)炎外敷中藥方關(guān)聯(lián)規(guī)則的研究[J].中醫(yī)正骨,2012,24(01):32-34.
　CHEN Hai-dong*,WANG Pei-min,FAN Jing..Study of externally applied traditional Chinese medicine prescription in treament of knee osteoarthritis on the association rules[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2012,24(01):32-34.
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膝骨性關(guān)節(jié)炎外敷中藥方關(guān)聯(lián)規(guī)則的研究()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第24卷
期數(shù):
2012年01期
頁(yè)碼:
32-34
欄目:
骨關(guān)節(jié)炎
出版日期:
2012-01-31

文章信息/Info

Title:
Study of externally applied traditional Chinese medicine prescription in treament of knee osteoarthritis on the association rules
作者:
陳海東1; 王培民2; 范競(jìng)2
1.南京中醫(yī)藥大學(xué)第一臨床醫(yī)學(xué)院,江蘇 南京 210046;
2.江蘇省中醫(yī)院,江蘇 南京 210029
Author(s):
CHEN Hai-dong*; WANG Pei-min; FAN Jing.
*The first clinical college of Nanjing university of Chinese Medicine,Nanjing 210046,Jiangsu,China
關(guān)鍵詞:
骨關(guān)節(jié)炎; 膝 中藥外敷 方劑分析; 計(jì)算機(jī)輔助 數(shù)據(jù)挖掘 關(guān)聯(lián)規(guī)則
Keywords:
Osteoarthritis; knee;  External applications(TCD);  Formula anal comput assist;  Data mining;  Association rules
摘要:
目的:探討治療膝骨性關(guān)節(jié)炎的外敷中藥方中各組成藥物間的關(guān)聯(lián)規(guī)則和用藥規(guī)律,為臨床應(yīng)用中藥外敷法治療膝骨性關(guān)節(jié)炎提供循證醫(yī)學(xué)依據(jù)。方法:應(yīng)用計(jì)算機(jī)檢索中國(guó)知網(wǎng)期刊全文數(shù)據(jù)庫(kù)收錄的1996年1月至2011年9月發(fā)表的關(guān)于中藥外敷治療膝骨性關(guān)節(jié)炎的文章,收集文章中所載的外敷用中藥方128個(gè),應(yīng)用Access2003數(shù)據(jù)庫(kù)軟件,錄入各藥方的組成藥物、劑量和用法,并記錄文章發(fā)表的時(shí)間和期刊名稱。對(duì)數(shù)據(jù)庫(kù)中的數(shù)據(jù)進(jìn)行統(tǒng)計(jì)、分析,找到使用頻次最多的藥物,然后進(jìn)行關(guān)聯(lián)規(guī)則計(jì)算。結(jié)果:128個(gè)膝骨性關(guān)節(jié)炎中藥外敷方中,藥物的總使用頻次為1 491次,使用頻次最多的15種藥物依次為草烏、川烏、山藥、當(dāng)歸等; 關(guān)聯(lián)規(guī)則計(jì)算后,支持度>16%、置信度>60%的藥對(duì)共有6對(duì),分別是川烏和草烏、乳香和沒(méi)藥、當(dāng)歸和牛膝、威靈仙和川烏、伸筋草和透骨草、伸筋草和紅花。結(jié)論:中藥外敷治療膝骨性關(guān)節(jié)炎,外敷方的藥物組成主要為具有溫經(jīng)散寒、搜風(fēng)通絡(luò)、活血散瘀、勝濕止痛、舒筋活絡(luò)等功效的藥物,臨床可根據(jù)具體證型靈活配伍應(yīng)用。
Abstract:
Objective:To explore the association rules and pharmic method of externally applied traditional Chinese medicine(TCM)prescription in the treatment of knee osteoarthritis,so as to provide evidence from the standpoint of Evidence-Base-Medicine.Methods:Literatures of external application of TCM in knee osteoarthritis published from January 1996 to September 2011 were retrieved from Science Direct On Site of China national knowledge infrastructure(CNKI)through computers.One hundred and twenty-eight kinds of externally applied TCM prescriptions were collected from the literatures.The ingredients,dosage and usage of the 128 kinds of TCM were input into database through Access2003 software,and the publication dates of literatures and journal names were recorded.The drugs with the most times of usage were found through the statistics and analysis of the data in the database,then they were processed with association rules calculation.Results:The total frequency of the drugs in the 128 prescriptions was 1 491,and the following 15 kinds of drugs were found with the highest occurrence frequency as radix aconiti kusnezoffii,radix aconiti,dioscorea opposita,angelica sinensis,etc.The result of association rules calculation showed that there were following 6 couples of drugs with support above 16% and confidence above 60% as radix aconiti kusnezoffii coupled with radix aconiti,olibanum coupled with myrrha,angelica sinensis coupled with achyranthes bidentata,clematis chinensis coupled with radix aconiti,herba lycopodii coupled with tuberculate speranskia herb and radix aconiti,herba lycopodii coupled with carthamus tinctorius.Conclusion:For external application of TCM in the treatment of knee osteoarthritis,the main pharmic ingredients of the prescriptions are the drugs with the effect of warming meridian and vessels,dispelling wind-evil,removing the wind,dredging collaterals,activating blood,removing blood stasis,eliminating dampness for relieving pain,relieving muscle and tendon and dredging the channels and collaterals,which can be compatible appllied flexibly according to the specific type of syndrome in clinic.

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備注/Memo

備注/Memo:
基金項(xiàng)目:國(guó)家科技部“十一五”國(guó)家科技支撐計(jì)劃項(xiàng)目(2008BAI53B033)
通訊作者:王培民 E-mail:[email protected]
更新日期/Last Update: 2012-01-20