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[1]張欲燃,湯遜,熊成東,等.可吸收椎體內(nèi)支撐器的研制及植入途徑研究[J].中醫(yī)正骨,2011,23(07):20-24.
　ZHANG Yu-ran*,TANG Xun,XIONG Cheng-dong,et al.Development of centrum-vertebra-fracture-repairing absorbable supporting plugger and the study of its implantation pathway[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2011,23(07):20-24.
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可吸收椎體內(nèi)支撐器的研制及植入途徑研究()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第23卷
期數(shù):
2011年07期
頁碼:
20-24
欄目:
基礎研究
出版日期:
2011-07-30

文章信息/Info

Title:
Development of centrum-vertebra-fracture-repairing absorbable supporting plugger and the study of its implantation pathway
作者:
張欲燃1; 湯遜2; 熊成東3; 張茂樞2; 徐永清2; 周田華 2; 劉力2
1.河南省濮陽市中醫(yī)院,河南 濮陽 457000;
2.中國人民解放軍成都軍區(qū)昆明總醫(yī)院, 云南 昆明 650032;
3.中國科學院成都有機化學研究所,四川 成都 610041
Author(s):
ZHANG Yu-ran*; TANG Xun; XIONG Cheng-dong; et al.*
Hospital of Chinese medicine of Puyang city,Puyang 457000,Henan,China
關鍵詞:
脊柱骨折 椎體成形術 可吸收椎體內(nèi)支撐器
Keywords:
Spinal fractures;  Vertebroplasty;  centrum-vertebra-fracture-repairing absorbable supporting plugger
摘要:
目的:研制用于胸腰椎骨折椎體重建的可吸收椎體內(nèi)支撐器,并探討經(jīng)椎弓根植入的可行性。方法:選擇100例健康成年志 愿者,CT掃描其T11～L4椎骨,模擬重建T11～L4椎骨的二維、三維圖像,測量椎 體矢狀徑、橫徑和椎弓根內(nèi)徑高度、寬度。據(jù)此確定可植入支撐器的規(guī)格,并以聚-DL-乳酸(分子量40～80萬)、磷酸三鈣或羥基 磷灰石為原料制成成品試件。將成品試件經(jīng)椎弓根植入3具成人尸體標本的L1、L2椎體中,完成后攝腰 椎標本正側位X線片,并行L1、L2椎骨CT掃描、矢狀面二維重建。結果:T11～ L4椎體橫徑(32.44±2.82)～(42.13±4.10)mm,椎體矢狀徑(25.55±2.54)～(28.97±2.24)mm; T11～L4椎弓根內(nèi)徑高度(9.16±1.40)～(12.46±1.67)mm,椎弓根內(nèi)徑寬度(5.78±0.89) ～(8.88±1.51)mm,椎弓根內(nèi)徑高度及寬度兩側相比,差異無統(tǒng)計學意義(T11～L4椎弓根內(nèi)徑高 度:t=1.857,P=0.334; t=1.673,P=0.707; t=2.355,P=0.685; t=1.983,P=0.126; t=2.435,P=0.148; t=2.871,P=0.774。 T11～L4椎弓根內(nèi)徑寬度:t=0.134,P=0937; t=1.962,P=0.125; t=0.453,P=0.634; t=1.983,P=0.509; t=1.643,P=0.086; t=0.851,P=0.150)。②設計的系列可吸收椎體內(nèi)支撐器規(guī)格為:長20.0～27.0 mm,寬7.0～10.0 mm,高9.0～ 12.0 mm。③經(jīng)X線及CT檢查,經(jīng)椎弓根植入3具成人尸體標本L1、L2椎體中的可吸收椎體內(nèi)支撐器位置 良好。結論:可吸收椎體內(nèi)支撐器經(jīng)椎弓根或經(jīng)椎弓根及其外側壁植入重建胸腰椎前中柱是可行的。
Abstract:
Objective:To develop the centrum-vertebra-fracture-repairing absorbable supporting plugger(CASP)used for the vertebral reconstruction after the thoracolumbar fractures,and to explore the feasibility of CASP's implantation via the pedicle of vertebral arch.Methods:One hundred healthy adult volunteers were chosen to reconstruct the 2D and 3D images of T11-L4 vertebras through CT scanning their T11-L4 vertebras,then the vertebral sagittal diameters,the vertebral transverse diameters, heights and widths of pedicle of vertebral arch were measured from above images.After that,the specifications of the implantable supporting pluggers were determined according to above measurements,and the finished product were manufactured from the following 3 materials as poly-DL-lacti acid(molecular weights ranged from 400,000 to 800,000),tricalcium phosphate and hydroxyapatite.The finished product were implanted into L1 vertebra and L2 vertebra of 3 adult cadavers via their pedicles of vertebral arch respectively.Next,PA&LAT X-ray films of the lumbar of cadavers were taken and conserved,L1 vertebra and L2 vertebra were scanned by CT and the image of their sagittal planes were processed with two-dimensional reconstruction.Results:①The transverse diameters of T11-L4 vertebras ranged from(32.44±2.82)mm to(42.13±4.10)mm,and their sagittal diameters ranged from (25.55±2.54)mm to(28.97±2.24)mm; the inner heights of pedicle of vertebral arch ranged from (9.16±1.40)mm to(12.46±1.67)mm,and their inner widths ranged from(5.78±0.89)mm to (8.88±1.51)mm,and there was no statistical difference in the inner heights and inner widths between the both sides of the pedicles of vertebral arch(Inner heights:t=1.857,P=0.334; t=1.673,P=0.707; t=2.355,P=0.685; t=1.983,P=0.126; t=2.435,P=0.148; t=2.871,P=0.774.Inner widths:t=0.134,P=0937; t=1.962,P=0.125; t=0.453,P=0.634; t=1.983,P=0.509; t=1.643,P=0.086; t=0.851,P=0.150).②The specifications of the designed CASP series were as follows:the lengths ranged from 20.0mm to 27.0mm,the widths ranged from 7.0mm to 10.0mm and the heights ranged from 9.0mm to 12.0mm.③The positions of CASP implanted into the L1 vertebra and L2 vertebra of the 3 adult cadavers from their pedicles of vertebral arch were turned out to be well after experiencing the inspection through X-ray and CT scanning.Conclusion:It is feasible to reconstruct the anterior columns and axial columns of thoracolumbar vertebrae through implanting CASP via pedicle or via the pedicle and its lateral wall.

參考文獻/References:

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更新日期/Last Update: 2011-07-30