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[1]盧建華,王維佳,陳明濤,等.補(bǔ)腎方對去卵巢大鼠腰椎骨形態(tài)計(jì)量學(xué)的影響[J].中醫(yī)正骨,2011,23(05):24-26.
　LU Jian-hua*,WANG Wei-jia,CHEN Ming-tao,et al.Effect of BuShenfang on morphometry of lumbar vertebra in Ovariectomized Rats[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2011,23(05):24-26.
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補(bǔ)腎方對去卵巢大鼠腰椎骨形態(tài)計(jì)量學(xué)的影響()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第23卷
期數(shù):
2011年05期
頁碼:
24-26
欄目:
基礎(chǔ)研究
出版日期:
2011-05-30

文章信息/Info

Title:
Effect of BuShenfang on morphometry of lumbar vertebra in Ovariectomized Rats
作者:
盧建華1; 王維佳1; 陳明濤1; 華江1; 萬蕾2; 何劍星3
1.浙江中醫(yī)藥大學(xué)附屬第一醫(yī)院,浙江 杭州 310006;
2.浙江省上虞市中醫(yī)院, 浙江 上虞 312000;
3.中國人民解放軍武裝警察部隊(duì)浙江總隊(duì)杭州醫(yī)院,浙江 杭州 310053
Author(s):
LU Jian-hua*; WANG Wei-jia; CHEN Ming-tao; et al.*
The first Hospital affiliated to Zhejiang Traditional Chinese Medical University,Hangzhou 310006,Zhejiang China
關(guān)鍵詞:
骨質(zhì)疏松癥 左歸丸 右歸丸 去卵巢大鼠 骨組織形態(tài)計(jì)量學(xué)
Keywords:
Osteoporosis; zuoguowan; youguiwan; Ovariectomized Rats; morphometry
摘要:
目的:研究補(bǔ)腎方(左歸丸、右歸丸)對去卵巢大鼠腰椎骨形態(tài)計(jì)量學(xué)的影響,為補(bǔ)腎方治療骨質(zhì)疏松癥提供有力的實(shí)驗(yàn)依據(jù)。方法:將成年SD大鼠50只,隨機(jī)分為正常對照組、模型組、陽性對照組、左歸丸組、右歸丸組,每組10只。造模后第13周開始給藥,正常對照組、模型組予蒸餾水灌胃,陽性對照組、左歸丸組、右歸丸組分別予倍美力水溶液、左歸丸煎劑和右歸丸煎劑灌胃,給藥12周末檢測第2腰椎骨形態(tài)計(jì)量學(xué)指標(biāo)。結(jié)果:左歸丸、右歸丸組與模型組比較,腰椎形態(tài)計(jì)量學(xué)指標(biāo)明顯改善(P<0.05),與陽性對照組比較,差異無統(tǒng)計(jì)學(xué)意義(P>0.05); 補(bǔ)腎藥物左歸丸組與右歸丸組比較,差異亦無統(tǒng)計(jì)學(xué)意義(P>0.05)。結(jié)論:補(bǔ)腎方能夠抑制骨吸收,減少骨量的丟失,對去卵巢大鼠骨質(zhì)疏松癥具有一定的治療作用。
Abstract:
Objective:To study the Effect of BuShenfang on morphometry of lumbar vertebra in Ovariectomized Rats,also to provid experimental evidence for treating Osteoporosis. Methods:The 50 Ovariectomized SD Rats were randomly divided into normal control group,model group,positive control(OVX)group,Zuoguiwan and Youguiwan group,each group with 10 Rats,after 12 weeks'routine feed,normal control group and model group which were intragastric administration with pure water,positive control group which was intragastric administration with conjugated estrogens water-solution,Zuoguiwan group which was intragastric administration with zuoguiwan decocta,Youguiwan group which was intragastric administration with youguiwan decocta, all the rats were intragastric administration following the schedule 12 weeks,then detect the index of morphometry of Second lumbar vertebra.Results:ComPared with model group,Bushenfang(including zuoguiwan and youguiwan)can obviously improve index of morphometry of lumbar vertebra(P<0.05).while there was no statistical significance when compared with positive control group.Meantime,the effect of zuoguiwan group is similar to the youguiwan group(P>0.05).Conclusion:Bushenfang(including zuoguiwan and youguiwan)can obviously improve index of morphometry of lumbar vertebra,decrease the bone resorption,prevent the loss of bone,strengthen bone Vetrebrae,which can prevent and treat osteoporosis.Meantime,the effect of zuoguiwan group is similar to the youguiwan group.

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備注/Memo

備注/Memo:
基金項(xiàng)目:浙江省中醫(yī)藥管理局科研項(xiàng)目(NO.2008CA007)
更新日期/Last Update: 2011-05-30