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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:

第23卷

期數(shù):

2011年03期

頁碼:

6-8

欄目:

基礎(chǔ)研究

出版日期:

2011-03-30

文章信息/Info

Title:

Study on the change of bone mineral density around the knee joint after anterior cruciate ligament injury and meniscus injury

作者:

賀文楠¹; 蔣振剛¹; 董學(xué)亮²; 左新成³

1.河南省新鄉(xiāng)市中心醫(yī)院,河南 新鄉(xiāng) 453003;
2.河南省澠池縣人民醫(yī)院, 河南 澠池 472400;
3.中國人民解放軍第150中心醫(yī)院,河南 洛陽 471031

Author(s):

HE Wen-nan^*; JIANG Zhen-gang; DONG Xue-liang; et al.^*

The central hospital of Xinxiang city,Xinxiang 453003,Henan,China

關(guān)鍵詞:

膝關(guān)節(jié) 前交叉韌帶 半月板; 脛骨 骨密度 動物實驗 兔

Keywords:

Knee joint;  Anterior cruciate ligament;  Menisci; Tibal;  Bone density;  Animal experimentation;  Rabbits

摘要:

目的:觀察前交叉韌帶、半月板損傷后膝關(guān)節(jié)周圍骨密度的變化,探討其影響因素及可能的影響機制。方法:健康純種新西 蘭大白兔16只隨機分為前交叉韌帶切斷組8只,半月板切除+前交叉韌帶切斷組8只,分別于造模前、造模后第4、8、12周末測量膝 關(guān)節(jié)周圍4個目的區(qū)的骨密度,比較各目的區(qū)不同造模方法、不同時間點間骨密度的變化。結(jié)果:R3區(qū),A組骨密度低于B組,差異有 統(tǒng)計學(xué)意義(F=22.326,P=0.001); 各時間點間骨密度差異有統(tǒng)計學(xué)意義(F=7.031,P=0.033); R4區(qū),兩種造模方法間骨密度差異 有統(tǒng)計學(xué)意義(F=14.821,P=0.007),各時間點間骨密度差異有統(tǒng)計學(xué)意義(F=5.632,P =0.031); 造模方法和測量時間無交互作用 (R3區(qū):P=0.063; R4區(qū):P=0.055)。R1、 R2區(qū),造模方法間骨密度值差異均無統(tǒng)計學(xué)意義(F=2.330,P=0.057; F=1.960,P=0.081); 各時間點間骨密度值差異無統(tǒng)計學(xué)意義(F=2.190,P=0.074,F=2.510,P=0.067)。結(jié)論:前交叉韌帶切斷、半月板切除術(shù)后膝關(guān)節(jié) 周圍發(fā)生骨密度改變可能是適應(yīng)性骨重建作用的結(jié)果,關(guān)節(jié)不穩(wěn)、應(yīng)力改變是主要的影響因素。

Abstract:

Objective:To observe the change of bone mineral density(BMD)around the knee joint after anterior cruciate ligament(ACL)injury and meniscus injury,and to explore the influencing factors and the possible mechanism for the change.Methods:16 healthy New Zealand pure rabbits were randomly divided into ACL transection group(group A)and meniscectomy combined with ACL transection group(group B),8 cases in each group.BMD of the 4 regions of interesting around the knee joint of the rabbits were measured before model building and at the 4th,8th,12th weekend after model building respectively.The change of BMD of the 4 regions of interesting were compared between different methods of model building and between different time points.Results:In the region 3,BMD of group A was lower than that of group B,and there was statistical difference between the 2 groups (F=22.326,P=0.001); and there was statistical difference in BMD among different time points(F=7.031,P=0.033).In the region 4,there was statistical difference in BMD between the 2 methods of model building (F=14.821,P=0.007),and there was statistical difference in BMD among different time points(F=5.632,P=0.031),and there was no interaction between molding method and measurement time(region 3:P=0.063; region4:P=0.055).In the region 1 and region 2,there was no statistical difference in BMD between the different molding methods (F=2.330,P=0.057; F=1.960,P=0.081),and there was no statistical difference in BMD among the measurement time points(F=2.190,P=0.074,F=2.510,P=0.067).Conclusion:It is possible that BMD change around the knee joint after ACL transaction and meniscectomy is the result of adaptive bone remodeling,and joint instability and stress change may play an important role in the process.

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更新日期/Last Update: 2011-03-30