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[1]仇春濤,鄧敦,施杞,等.益氣活血壯骨方對去勢大鼠骨形態(tài)學(xué)的影響[J].中醫(yī)正骨,2011,23(03):3-5.
　QIU Chun-tao*,DENG Dun,SHI Qi,et al.Effect of Yiqihuoxue Zhuanggu decoction(益氣活血壯骨方)on bone morphology in castrated rats[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2011,23(03):3-5.
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益氣活血壯骨方對去勢大鼠骨形態(tài)學(xué)的影響()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第23卷
期數(shù):
2011年03期
頁碼:
3-5
欄目:
基礎(chǔ)研究
出版日期:
2011-03-30

文章信息/Info

Title:
Effect of Yiqihuoxue Zhuanggu decoction(益氣活血壯骨方)on bone morphology in castrated rats
作者:
仇春濤1; 鄧敦1; 施杞2; 王擁軍2
1.溫州醫(yī)學(xué)院附屬溫嶺醫(yī)院,浙江 溫嶺 317500;
2.上海中醫(yī)藥大學(xué),上海 200032
Author(s):
QIU Chun- tao*; DENG Dun; SHI Qi; et al.*
Wenling Hospital Affiliated to Wenzhou Medical College,Wenling 317500,Wenzhou,China
關(guān)鍵詞:
骨質(zhì)疏松 益氣活血 補腎養(yǎng)血 骨形態(tài)學(xué)
Keywords:
Osteoporosis;  Reinforcing QI activat blood;  Reinforcing kidney nour blood;  Bone Morphology
摘要:
目的:探討益氣活血壯骨方對去勢大鼠骨形態(tài)學(xué)的影響。方法:將45只6月齡雌性SD大鼠隨機分為5組:假手術(shù)組(A組)、模 型組(B組)、益氣活血壯骨方組(C組)、樂力膠囊組(D組)和骨松寶組(E組),每組9只。假手術(shù)組僅開腹縫合,其余4組做卵巢切除 術(shù)。術(shù)后4周,A、B組大鼠以生理鹽水灌胃(10 mL·kg-1),C組大鼠以益氣活血壯骨方灌胃(9.6 g·kg- 1),D組大鼠以樂力膠囊灌胃(0.15 g·kg-1),E組大鼠以骨松寶灌胃(8 g·kg-1),每天1次,連續(xù) 給藥12周。12周后處死大鼠,觀察各組大鼠骨小梁平均寬度、相對骨體積、單位面積骨小梁骨細胞數(shù)、平均骨皮質(zhì)厚度及股骨頭 平均灰度。結(jié)果:①A、C、D、E組大鼠的骨小梁平均寬度、相對骨體積、單位面積骨小梁骨細胞數(shù)、平均骨皮質(zhì)厚度及股骨頭平 均灰度均高于B組,差異有統(tǒng)計學(xué)意義(P<0.05); ②A、C組各項實驗指標(biāo)均高于D、E組,差異有統(tǒng)計學(xué)意義(P<0.05); ③A 、C組各項指標(biāo)差異無統(tǒng)計學(xué)意義(P>0.05),D、E組各項指標(biāo)差異無統(tǒng)計學(xué)意義(P>0.05)。結(jié)論:益氣活血壯骨方能提高去 勢大鼠骨小梁平均寬度、相對骨體積、單位面積骨小梁骨細胞數(shù)、平均骨皮質(zhì)厚度及股骨頭平均灰度,并能使其接近正常水平, 療效優(yōu)于樂力膠囊和骨松寶。
Abstract:
Objective:To explore the effect of Yiqihuoxue Zhuanggu(YQHXZG)decoction(益氣活血壯骨方)on bone morphology in castrated rats.Methods:45 rats were randomly divided into sham-operated group(group A),model group(group B),YQHXZG decoction group(group C),LELI(compound calcium amino acid chelate)capsules group(group D)and GUSONGBAO(a kind of traditional Chinese medicine)group(group E),9 cases in each group.The cases in group A were administrated with sham-operation only,while those in other groups were administrated with oophorectomy.4 weeks after operation,rats in group A and group B were lavaged with physiological saline(10 mL· kg-1),rats in group C were lavaged with YQHXZG decoction(9.6 g·kg-1),rats in group D were lavaged with LELI capsules(0.15 g·kg-1)and rats in group E were lavaged with GUSONGBAO(8 g·kg-1),once a day for consecutive 12 weeks.12 weeks later,all the rats were sacrificed.The average width of the bone trabecula,relative bone volume,cell population of bone trabecula in unit area,the average thickness of cortical bone and the average gray scale of femoral head of the rats were measured.Results:①The average width of the bone trabecula,relative bone volume,cell population of bone trabecula in unit area,the average thickness of cortical bone and the average gray scale of femoral head of the rats in group A,group C,group D and group E were higher than those of the rats in group B(P<0.05).②Every experimental index of group A and group C was higher than that of group D and group E(P<0.05).③There was no statistical difference in every experimental index between group A and group C(P>0.05),and there was no statistical difference in every experimental index between groupD and group E(P>0.05).Conclusion:Yiqihuoxue Zhuanggu decoction(益氣活血壯骨方),which performs better than LELI capsules and GUSONGBAO,can elevate the following index as the average width of the bone trabecula,relative bone volume,cell population of bone trabecula in unit area,the average thickness of cortical bone and the average gray scale of femoral head of the castrated rats,and make them close to normal levels.

參考文獻/References:

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備注/Memo

備注/Memo:
基金項目:國家教育部重點學(xué)科項目,上海市重點學(xué)科項目(第二期)(T0303)
通訊作者:鄧敦 E-mail:dengdun198425@126.com
更新日期/Last Update: 2011-03-30