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[1]周新凱,李漢,王墉琦,等.淀粉樣前體蛋白和β-淀粉樣蛋白對骨質(zhì)疏松癥影響的研究進展[J].中醫(yī)正骨,2025,37(03):57-60,64.
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淀粉樣前體蛋白和β-淀粉樣蛋白對骨質(zhì)疏松癥影響的研究進展()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第37卷
期數(shù):
2025年03期
頁碼:
57-60,64
欄目:
綜述
出版日期:
2025-03-20

文章信息/Info

作者:
周新凱1李漢2王墉琦2李佳2孫晴2孫義軍2
1.陜西中醫(yī)藥大學(xué)第一臨床醫(yī)學(xué)院,陜西 咸陽 712046; 2.西安市中醫(yī)醫(yī)院,陜西 西安 710021
關(guān)鍵詞:
骨質(zhì)疏松 阿爾茨海默病 淀粉樣β蛋白前體 淀粉樣β-蛋白 綜述
摘要:
骨質(zhì)疏松癥(osteoporosis,OP)和阿爾茨海默病(Alzheimer disease,AD)均為老年人群體中高發(fā)的退行性疾病。AD的關(guān)鍵病理因子淀粉樣前體蛋白(amyloid precursor protein,APP)和β-淀粉樣蛋白(amyloid β-protein,Aβ)在OP患者的骨組織中異常沉積,提示二者可能參與OP的病理進程。本文結(jié)合近年相關(guān)文獻,從骨吸收和骨形成2個方面對APP和Aβ對OP的影響進行了綜述。

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備注/Memo

備注/Memo:
基金項目:陜西省重點研發(fā)計劃項目(2019SF-282); 西安市科技計劃項目[20YXYJ0012(4)]
通訊作者:孫晴 E-mail:[email protected]
更新日期/Last Update: 1900-01-01