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[1]劉柏良,秦瑨,劉小榮,等.miR-27a參與骨肉瘤發(fā)生發(fā)展作用機制的研究進展[J].中醫(yī)正骨,2025,37(03):53-56.
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miR-27a參與骨肉瘤發(fā)生發(fā)展作用機制的研究進展()
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《中醫(yī)正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第37卷
期數(shù):
2025年03期
頁碼:
53-56
欄目:
綜述
出版日期:
2025-03-20

文章信息/Info

作者:
劉柏良1秦瑨1劉小榮2張懷斌1王勇平3
1.蘭州大學第一臨床醫(yī)學院,甘肅 蘭州 730000; 2.海南醫(yī)科大學第二附屬醫(yī)院,海南 海口 570311; 3.蘭州大學第一醫(yī)院,甘肅 蘭州 730000
關鍵詞:
骨肉瘤 微RNAs 分子機制 綜述
摘要:
骨肉瘤是兒童和青少年中最常見的原發(fā)性惡性骨腫瘤,其發(fā)病機制復雜,目前仍缺乏有效的治療方法。尋找可靠的生物標志物與分子靶點是骨肉瘤診治工作中亟待解決的問題。miR-27a對腫瘤細胞的增殖、侵襲、遷移和凋亡具有關鍵的調(diào)控作用,與骨肉瘤的發(fā)生發(fā)展關系密切,同時也影響著骨肉瘤患者的藥物敏感性和預后。為進一步了解miR-27a在骨肉瘤發(fā)生發(fā)展中的作用,為骨肉瘤的基礎研究和臨床治療提供思路,本文概述了miR-27a的生物學特征,從調(diào)控信號通路及參與細胞代謝重編程2個方面對miR-27a參與骨肉瘤發(fā)生發(fā)展的作用機制進行了綜述。

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備注/Memo

備注/Memo:
基金項目:甘肅省高校產(chǎn)業(yè)支撐計劃項目(2023CYZC-03); 蘭州市人才創(chuàng)新創(chuàng)業(yè)項目(2021-RC-114)
通訊作者:王勇平 E-mail:[email protected]
更新日期/Last Update: 1900-01-01